Abstract
The past two decades has seen a significant increase in both popular and scientific interest in psychedelic substances and plants as therapeutics for mental illness, addictions, and psychospiritual suffering. Current psychiatric practice privileges a biological paradigm in which the brain is considered the locus of mental illness and symptom-focused treatments are delivered to patients as passive recipients. In contrast, a psychedelic healing paradigm, constructed through examination of different ontologic understandings of plant medicines, is based on a complex multidimensional perspective of human beings and their suffering. This paradigm actively engages the sufferer in addressing root causes of illness through healing on multiple levels of existence, including spiritual and energetic domains. Numerous theoretical, methodological, and ethical challenges complicate the integration of the psychedelic healing paradigm into psychiatric practice. These include developing coherent therapeutic narratives that account for the complex processes by which psychedelic healing occurs and overcoming reductionist tendencies in the medical sciences. Tasked with overcoming such challenges, a model clinic is proposed that seeks to implement and study the psychedelic healing paradigm in a critical, interdisciplinary, and reflexive manner. Such “critical paradigm integration” would employ multimodal patient formulation and treatments, as well as a range of knowledge generation and sharing practices. Outcomes-oriented research would seek to establish an evidence base for the model, while critical dialogues would advance understandings of psychedelic substances and plants and related practices more generally. The clinic would serve as proof of concept for a new model of studying, conceptualizing, and treating mental illness.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
A note about terminology: There are currently debates about how psychedelic substances or molecules are similar to or different from plants or plant-based preparations containing psychoactive (as well as other) compounds. The latter are commonly referred to as “plant medicines” by enthusiasts and some academics. The nuances of this debate are beyond the scope of this chapter, which will give preference to the more neutral and inclusive term “psychedelic substances and plants,” as most points being made about psychedelic healing apply to both.
- 2.
Effective clinicians may also imbue these treatments with additional meaning and target patient expectancy in order to boost the placebo effect of the intervention.
- 3.
By energetic, I refer to Eastern conceptions of physiology and pathophysiology involving energetic channels, meridians, and centers (or chakras), such as in traditional Chinese medicine or Ayurveda, as well as shamanic notions of energy.
- 4.
Details of this approach will be discussed further in the second half of the chapter.
- 5.
“Target engagement” refers to verification that the intervention has had the predicted effect on the target (National Institute of Mental Health, 2013). This has recently become a requirement to receive grant money from the National Institute of Mental Health (NIMH).
- 6.
This kind of work is being conducted by the Nierika Intercultural Medicine Institute (Nierika, n.d.).
- 7.
Rescheduling of a substance requires demonstrating therapeutic efficacy through large-scale, randomized, placebo-controlled clinical trials in which the substance itself is isolated as the variable that leads to changes in therapeutic outcomes while controlling for all other variables.
References
Abramson, H. A. (1967). The use of LSD in psychotherapy and alcoholism. Indianapolis, IN: Bobbs-Merrill.
Auer, P. (2013). Code-switching in conversation. New York, NY: Routledge.
Barrett, F. S., Bradstreet, M. P., Leoutsakos, J. M. S., Johnson, M. W., & Griffiths, R. R. (2016). The challenging experience questionnaire: Characterization of challenging experiences with psilocybin mushrooms. Journal of Psychopharmacology, 30(12), 1279–1295. https://doi.org/10.1177/0269881116678781.
Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M. H., Vogel, Z., … Mechoulam, R. (1998). An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology, 353(1), 23–31.
Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P., & Strassman, R. J. (2015). Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology, 29(3), 289–299. https://doi.org/10.1177/0269881114565144.
Bracken, P., Thomas, P., Timimi, S., Asen, E., Behr, G., Beuster, C., … Yeomans, D. (2012). Psychiatry beyond the current paradigm. The British Journal of Psychiatry, 201(6), 430–434. https://doi.org/10.1192/bjp.bp.112.109447.
Brown, T. K., & Alper, K. (2017). Treatment of opioid use disorder with ibogaine: Detoxification and drug use outcomes. The American Journal of Drug and Alcohol Abuse, 44(1), 1–13. https://doi.org/10.1080/00952990.2017.1320802.
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., … Nutt, D. J. (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences, 109(6), 2138–2143. https://doi.org/10.1073/pnas.1119598109.
Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., … Nutt, D. J. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences, 113(17), 4853–4858. https://doi.org/10.1073/pnas.1518377113.
Carlat, D. (2010). Unhinged. New York, NY: Simon and Schuster.
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., la Fuente Revenga, de, M., … Riba, J. (2016). Ayahuasca: Pharmacology, neuroscience and therapeutic potential. Brain Research Bulletin, 126(Part 1), 89–101. https://doi.org/10.1016/j.brainresbull.2016.03.002.
El-Seedi, H. R., Smet, P. A. G. M. D., Beck, O., Possnert, G., & Bruhn, J. G. (2005). Prehistoric peyote use: Alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas. Journal of Ethnopharmacology, 101(1–3), 238–242. https://doi.org/10.1016/j.jep.2005.04.022.
Engel, G. L. (1980). The clinical application of the biopsychosocial model. American Journal of Psychiatry, 137(5), 535–544.
Fábregas, J. M., González, D., Fondevila, S., Cutchet, M., Fernández, X., Barbosa, P. C. R., … Bouso, J. C. (2010). Assessment of addiction severity among ritual users of ayahuasca. Drug and Alcohol Dependence, 111(3), 257–261. https://doi.org/10.1016/j.drugalcdep.2010.03.024.
Garcia-Romeu, A., Griffiths, R. R., & Johnson, M. W. (2014). Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction. Current Drug Abuse Reviews, 7(3), 157–164.
Goff, D. C., Falkai, P., Fleischhacker, W. W., Girgis, R. R., Kahn, R. M., Uchida, H., … Lieberman, J. A. (2017). The long-term effects of antipsychotic medication on clinical course in schizophrenia. American Journal of Psychiatry, 174(9), 840–849. https://doi.org/10.1176/appi.ajp.2017.16091016.
Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., … Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology, 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513.
Griffiths, R. R., Johnson, M. W., Richards, W. A., Richards, B. D., McCann, U., & Jesse, R. (2011). Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects. Psychopharmacology, 218(4), 649–665. https://doi.org/10.1007/s00213-011-2358-5.
Grof, S. (1994). LSD psychotherapy. Alameda, CA: Hunter House.
Halpern, J. H., Sherwood, A. R., Hudson, J. I., Yurgelun-Todd, D., & Pope, H. G., Jr. (2005). Psychological and cognitive effects of long-term peyote use among Native Americans. Biological Psychiatry, 58(8), 624–631. https://doi.org/10.1016/j.biopsych.2005.06.038.
Halpern, J. H., Sherwood, A. R., Passie, T., Blackwell, K. C., & Ruttenber, A. J. (2008). Evidence of health and safety in American members of a religion who use a hallucinogenic sacrament. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 14(8), SR15–SR22.
Hendy, K. (2018). The placebo paradox. In B. C. Labate & C. Cavnar (Eds.), Plant medicines, healing and psychedelic science: Cultural perspectives. Heidelberg: Springer.
Johnson, M. W., Garcia-Romeu, A., & Griffiths, R. R. (2016). Long-term follow-up of psilocybin-facilitated smoking cessation. The American Journal of Drug and Alcohol Abuse, 1–6. https://doi.org/10.3109/00952990.2016.1170135.
Johnson, M., Richards, W., & Griffiths, R. (2008). Human hallucinogen research: Guidelines for safety. Journal of Psychopharmacology, 22(6), 603–620. https://doi.org/10.1177/0269881108093587.
Kellert, S. R., Heerwagen, J., & Mador, M. (2011). Biophilic design. San Francisco, CA: Wiley.
Kleinman, A. (1988). The illness narratives. New York, NY: Basic Books.
Labate, B. C., & Cavnar, C. (2013). The therapeutic use of ayahuasca. New York, NY: Springer. https://doi.org/10.1007/978-3-642-40426-9.
Labate, B. C., & Cavnar, C. (2014). Ayahuasca shamanism in the Amazon and beyond. New York, NY: Oxford University Press.
Labate, B. C., Cavnar, C., & Gearin, A. K. (2016). The world ayahuasca diaspora. New York, NY: Routledge.
Leary, T., Metzner, R., & Alpert, R. (1995). The psychedelic experience. New York, NY: Citadel Press.
Lewis, B. (2011). Narrative psychiatry. Baltimore, MD: JHU Press.
Luna, L. E. (1984). The concept of plants as teachers among four mestizo shamans of Iquitos, northeastern Peru. Journal of Ethnopharmacology, 11(2), 135–156.
Millenium Villages Project. (n.d.). Millennium villages |Overview. Retrieved from http://millenniumvillages.org/about/overview/
Moynihan, R., & Cassels, A. (2006). Selling sickness. New York, NY: Nation Books.
National Institute of Mental Health. (2013, December 7). NIMH’s new focus in clinical trials. Retrieved from https://www.nimh.nih.gov/funding/grant-writing-and-application-process/concept-clearances/2013/nimhs-new-focus-in-clinical-trials.shtml
Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264–355. https://doi.org/10.1124/pr.115.011478.
Nierika. (n.d.). The Nierika Intercultural Medicine Institute. Retrieved from http://nierika.info/english/medicine-institute/
Olfson, M., & Marcus, S. C. (2010). National trends in outpatient psychotherapy. American Journal of Psychiatry, 167(12), 1456–1463. https://doi.org/10.1176/appi.ajp.2010.10040570.
Palhano-Fontes, F., Barreto, D., Onias, H., & Andrade, K. C. (2017). Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: A randomised placebo-controlled trial. Biorxiv, 103531. https://doi.org/10.1101/103531.
Pollan, M. (2007, January 28). Unhappy meals. Retrieved from http://michaelpollan.com/articles-archive/unhappy-meals/
Ribeiro, S. (2018). Whole organisms or pure compounds? Entourage effect versus drug specificity. In B. C. Labate & C. Cavnar (Eds.), Plant medicines, healing and psychedelic science: Cultural perspectives. Heidelberg: Springer.
Richards, W. A. (2015). Sacred knowledge. New York, NY: Columbia University Press. https://doi.org/10.7312/rich17406.
Ross, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., … Schmidt, B. L. (2016). Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial. Journal of Psychopharmacology, 30(12), 1165–1180. https://doi.org/10.1177/0269881116675512.
Ryan, C. O., Browning, W. D., Clancy, J. O., Andrews, S. L., & Kallianpurkar, N. B. (2014). Biophilic design patterns: Emerging nature-based parameters for health and well-being in the built environment. International Journal of Architectural Research: ArchNet-IJAR, 8(2), 62–76.
Samara, M. T., Dold, M., Gianatsi, M., Nikolakopoulou, A., Helfer, B., Salanti, G., & Leucht, S. (2016). Efficacy, acceptability, and tolerability of antipsychotics in treatment-resistant schizophrenia. JAMA Psychiatry, 73(3), 199–112. https://doi.org/10.1001/jamapsychiatry.2015.2955.
Sanacora, G., & Schatzberg, A. F. (2014). Ketamine: Promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology, 40(2), 259–267. https://doi.org/10.1038/npp.2014.261.
Sherwood, J. N., & Stolaroff, M. J. (1962). The psychedelic experience: A new concept in psychotherapy. Journal of Neuropsychiatry, 4, 69–80. https://doi.org/10.1080/02791072.1968.10524522.
Tafur, J. (2017). The fellowship of the river: A medical doctor’s exploration into traditional Amazonian plant medicine. Phoenix, AZ: Espiritu Books.
Thomas, G., Lucas, P., Capler, N. R., Tupper, K. W., & Martin, G. (2013). Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada. Current Drug Abuse Reviews, 6(1), 30–42.
Tindle, H. A., Davis, R. B., & Phillips, R. S. (2005). Trends in use of complementary and alternative medicine by US adults: 1997–2002. Therapies in Health, 11(1), 42–49.
Torres, C. M. (1995). Archaeological evidence for the antiquity of psychoactive plant use in the Central Andes. Annuli Dei Musei Civici Roverero, 11, 391–326.
Tupper, K. W., & Labate, B. C. (2014). Ayahuasca, psychedelic studies and health sciences: The politics of knowledge and inquiry into an Amazonian plant brew. Current Drug Abuse Reviews, 7(2), 71–80.
United States Drug Enforcement Administration. (n.d.). Drug scheduling. Retrieved from https://www.dea.gov/druginfo/ds.shtml
Warden, D., Rush, A. J., Trivedi, M. H., Fava, M., & Wisniewski, S. R. (2007). The STAR* D Project results: A comprehensive review of findings. Current Psychiatry Reports, 9(6), 449–459.
Wilkinson, S. T., Wright, D., Fasula, M. K., Fenton, L., Griepp, M., Ostroff, R. B., & Sanacora, G. (2017). Cognitive behavior therapy may sustain antidepressant effects of intravenous ketamine in treatment-resistant depression. Psychotherapy and Psychosomatics, 86(3), 162–167. https://doi.org/10.1159/000457960.
World Ayahuasca Conference. (2016). Open letter from the Indigenous people of Acre, Brazil. Retrieved from http://www.ayaconference.com/index.php/conclusoes?lang=en
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Sloshower, J. (2018). Integrating Psychedelic Medicines and Psychiatry: Theory and Methods of a Model Clinic. In: Labate, B., Cavnar, C. (eds) Plant Medicines, Healing and Psychedelic Science. Springer, Cham. https://doi.org/10.1007/978-3-319-76720-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-76720-8_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-76719-2
Online ISBN: 978-3-319-76720-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)