Abstract
In this chapter, we present the formation and modeling techniques of two important sensing devices built out of engineered artificial membranes: the Ion Channel Switch (ICS) biosensor, and the Electroporation Measurement Platform (EMP). The ICS biosensor can be used to detect femto-molar concentrations of analyte species in an electrolyte solution, and the EMP is used to study the dynamics of electroporation in engineered membranes. The engineered membrane in the ICS and EMP are design to mimic the electrophysiological properties of real cell membranes. Common to both platforms is the bioelectronic interface for performing electrical measurements. Experimental measurements of the two platforms are performed by estimating the current response of the engineered membrane which depends on the charging dynamics at the bioelectronic interface and membrane, as well as dynamics of aqueous pores and conducting ion-channels in the membrane.
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- 1.
A biomimetic system is a physical device that contains the features of a biological system. This is similar to an in vivo system in which biological molecules are used outside their normal biological environment.
- 2.
Ex vivo means which take place outside the normal membrane environment in a cell, but with minimal alterations from the natural conditions of the membrane.
- 3.
The evaluation of the fractional order derivative can be performed using the Adomian decomposition method [18] which is a popular semi-analytical method for solving ordinary and non-linear partial differential equations. Another method is the Variational iteration method [19] typically used for numerically solving non-linear partial differential equations. Linear multistep methods, such as the Adams-Bashforth-Moulton [20], can also be used to evaluate the fractional order derivative.
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Appendix
Appendix
All experimental measurements using the ICS and EMP, unless otherwise stated, were conducted at 20 \(^{\circ }\)C in a phosphate buffered solution with a pH of 7.2, and a 0.15 M saline solution composed of Na\(^+\), K\(^+\), and Cl\(^-\). At this temperature the tethered membrane is in the liquid phase. A pH of 7.2 was selected to match that typically found in the cellular cytosol of real cells. The forward and reverse reaction rates in Table 2 are obtained from [10, 23, 50]. The electroporation parameters \(\alpha , q, C, D, r_m\) are obtained from [27, 32, 39, 40], \(\gamma , \sigma \) from [41], and \(W_\text {es}(r)\) and \(G_p(r)\) from [13]. Using impedance measurements it was determined that the fractional order operator p is in the range of 0.95 to 0.98 suggesting that a diffusion-limited process is present at the bioelectronic gold interface of the tethered archaebacterial membrane. The associated capacitance \(C_{dl}\) is in the range of 120–180 nF.
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Hoiles, W., Krishnamurthy, V. (2018). Macroscopic Models for the Bioelectronic Interface of Engineered Artificial Membranes. In: Bonilla, L., Kaxiras, E., Melnik, R. (eds) Coupled Mathematical Models for Physical and Biological Nanoscale Systems and Their Applications. BIRS-16w5069 2016. Springer Proceedings in Mathematics & Statistics, vol 232. Springer, Cham. https://doi.org/10.1007/978-3-319-76599-0_15
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