Future Avenues of Translational Care for Patients with Temporomandibular Joint Disorders

  • Francesco ChiappelliEmail author
  • André Barkhordarian
  • Eliseo B. SabalJr
  • Allen Khakshooy
  • G. Gary Demerjian


This chapter discusses the need for novel avenues and methodologies of fundamental and clinical research of translational healthcare for new and improved treatment of patients with TMD. It discusses certain aspects of current osteoarthritis and chondropathogenesis research, including the promising novel avenues of microRNA and genomic engineering research. The chapter discusses the extent to which these new approaches may improve the diagnosis and treatment and prognosis of patients with TMD in the next decades, with an emphasis on novel individual patient data research and analysis protocols and interpretation. Limitations and fallacies as currently entertained in the field are examined.


TMJ Disorders Translational Healthcare Lubricin Sclerostin Translational Effectiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Cluster randomized stepped wedge blinded controlled trial


Individual patient research and analysis




Receptor activator of nuclear factor κB ligand


Signal transducer and activator of transcription 3


Toll-like receptors


Temporomandibular joint disorders


Temporomandibular joint


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesco Chiappelli
    • 1
    • 2
    Email author
  • André Barkhordarian
    • 1
    • 2
  • Eliseo B. SabalJr
    • 3
  • Allen Khakshooy
    • 3
    • 4
  • G. Gary Demerjian
    • 1
    • 2
    • 5
  1. 1.UCLA School of DentistryLos AngelesUSA
  2. 2.Evidence-Based Decisions Practice-Based Research NetworkLos AngelesUSA
  3. 3.Division of Oral Biology and MedicineUCLA School of DentistryLos AngelesUSA
  4. 4.Rappaport Faculty of Medicine, Technion-Israel Institute of TechnologyHaifaIsrael
  5. 5.Center for TMJ & Sleep TherapyGlendoraUSA

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