Patient-Centered Outcomes Research and Collaborative Evidence-Based Medical and Dental Practice for Patients with Temporomandibular Joint Disorders

  • Francesco ChiappelliEmail author
  • André Barkhordarian
  • G. Gary Demerjian


This chapter discusses the fundamental principles of the research synthesis process in the context of treatment for TMD. It briefly introduces the ongoing controversy in the etiological factors that lead to TMD, which could be broadly divided into two schools of thought: (1) the muscular cause of TMD (disorders of the joint that occur as a result of excessive or dysregulated activities such as clenching and bruxism of the masticatory muscles) or (2) the articular cause of TMD (the disorders of the joint that are consequential to dysfunctional positioning of the mandible onto the maxillary bone, which itself may result from trauma to the facial skeletal structure, malocclusion particularly with respect to molar contact and support). The chapter discusses perspectives of the arthrokinetic reflex in TMD. The chapter defines the best available evidence and discusses the process leading to EBDM for treating TMD, including the generation and dissemination of evidence-based revisions of clinical practice guidelines (EBrCPGs).


Arthrokinetic reflex Cranial nerve V 



Evidence-based dentistry


Evidence-based clinical decision-making


Evidence-based revisions of clinical practice guidelines


Functional magnetic resonance imaging


Patient-centered outcomes evaluation


Temporomandibular joint disorders


Temporomandibular joint


World Health Organization


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesco Chiappelli
    • 1
    • 2
    Email author
  • André Barkhordarian
    • 1
    • 2
  • G. Gary Demerjian
    • 1
    • 2
    • 3
  1. 1.UCLA School of DentistryLos AngelesUSA
  2. 2.Evidence-Based Decisions Practice-Based Research NetworkLos AngelesUSA
  3. 3.Center for TMJ & Sleep TherapyGlendoraUSA

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