Abstract
The liver is designed to maintain the body’s chemical and metabolic homeostasis. It plays a major role in protein, carbohydrate, lipid, bile acid, and iron metabolism, and the body’s immune defense. About 90% of the body’s nutrients pass through the liver from the intestines. The liver is also responsible for the synthesis of many plasma proteins with different functions, and acts as a filter to remove harmful substances from the blood. Finally, it performs important endocrine functions. Knowledge of the relationship between structure and function of the liver under normal conditions is essential for understanding derangements observed in clinical diseases affecting the liver.
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References
Ger R. Surgical anatomy of the liver. Surg Clin North Am. 1989;69:179–92.
Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg. 1982;6:3–9.
Skandalakis JE, Skandalakis LJ, Skandalakis PN, Mirilas P. Hepatic surgical anatomy. Surg Clin North Am. 2004;84:413–35.
Jamieson GG. The anatomy of general surgical operations. 2nd ed. Edinburgh/New York: Churchill Livingstone/Elsevier; 2006. p. 8–23.
Kogure K, Ishizaki M, Nemoto M, Kuwano H, Yorifuji H, Ishikawa H, et al. Close relation between the inferior vena cava ligament and the caudate lobe in the human liver. J Hepato-Biliary-Pancreat Surg. 2007;14:297–301.
Ludwig J, Ritman EL, LaRusso NF, Sheedy PF, Zump G. Anatomy of the human biliary system studied by quantitative computer aided three-dimensional imaging techniques. Hepatology. 1998;27:893–9.
Blumgart LH, Belghiti J. Surgery of the liver, biliary tract, and pancreas. 3rd ed. Philadelphia: Saunders Elsevier; 2007. p. 3–30.
Sherlock S. Assessment of liver function. In: Sherlock S, editor. Disease of liver and biliary system. 10th ed. London: Blackwell Science Ltd; 1997. p. 17–32.
Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol. 2004;82:506–14.
Malandro MS, Kilberg MS. Molecular biology of amino acid transporters. Annu Rev Biochem. 1996;65:305–36.
Kadowaki M, Kanazawa T. Amino acids as regulators of proteolysis. J Nutr. 2003;133(6 Suppl 1):20525–65.
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, et al. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol. 2006;574:41–53.
Stinkens R, Goossens G, Jocken J, Blaak E. Targeting fatty acid metabolism to improve glucose metabolism. Obes Rev. 2015;16:715–57.
Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906–12.
Aisen P, Leibman A, Zweier J. Stoichiometric and site characteristics of the binding of iron to human transferrin. J Biol Chem. 1978;253:1930–7.
Weiss G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta. 2009;1790:682–93.
Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res. 2009;50:2340–57.
Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K. Targeting bile acid signalling for metabolic diseases. Nat Rev Drug Discov. 2008;7:678–93.
Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, Adachi Y. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol. 2000;35:659–64.
Chiang YIL. Bile acid metabolism and signaling. Compr Physiol. 2013;3:1191–212.
Maddrey W. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Gastroenterology. 2000;118:984–5.
Notas G, Kisseleva T, Brenner D. NK and NKT cells in liver injury and fibrosis. Clin Immunol. 2009;130:16–26.
Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology. 2006;43:S54–62.
Zakhari S. Overview: How is alcohol metabolized by the body? Alcohol Res Health. 2006;30:709–19.
Lieber CS. Metabolism of alcohol. Clin Liver Dis. 2005;9:1–35.
Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006;354:731–9.
Zieve L. Pathogenesis of hepatic encephalopathy. Metab Brain Dis. 1987;2:147–65.
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Virović-Jukić, L., Živković, M. (2018). Liver Function. In: Duvnjak, M., Smirčić-Duvnjak, L. (eds) Gastrointestinal Complications of Diabetes . Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-75856-5_20
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DOI: https://doi.org/10.1007/978-3-319-75856-5_20
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