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MCH and Thermoregulation

  • Marco Luppi
Chapter

Abstract

Homeothermy represents a remarkable step in animal evolution, albeit at a very high cost in terms of metabolic demand. The maintenance of core body temperature in mammals represents one of the prominent physiological components contributing to the basal metabolic rate. Homeostatic thermoregulation is coordinated by the central nervous system by means of different strategies, spanning from behavioral modifications, aimed at finding a better environment, to the activation or inhibition of key regulatory mechanisms, which are mainly driven by the autonomic nervous system. The hypothalamic neuropeptide MCH plays a pivotal role in regulating basal metabolism, and the activation of this system results in a slowing down of the metabolic rate and also stimulates food intake. On the contrary, blocking the MCH system, in animal models, promotes a lean phenotype with higher body temperature. Even though MCH is not involved in thermoregulatory processes, modifying MCH activity induces metabolic rate modifications, and thermoregulation is modified accordingly. The activation of the MCH system also leads to the dampening of the normal daily oscillation of body temperature. The well-known involvement of MCH in wake-sleep cycle regulation, by stabilizing sleep, and in particular REM sleep, reinforces the hypothesis that the functions of metabolism, thermoregulation, and sleep regulation are closely linked.

References

  1. Ahnaou A, Dautzenberg FM, Huysmans H, Steckler T, Drinkenburg WH (2011) Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: evidence from MCH1 (−/−) mice. Behav Brain Res 218:42–50CrossRefGoogle Scholar
  2. Amici R, Bastianini S, Berteotti C, Cerri M, Del Vecchio F, Lo Martire V, Luppi M, Perez E, Silvani A, Zamboni G, Zoccoli G (2014) Sleep and bodily functions: the physiological interplay between body homeostasis and sleep homeostasis. Arch Ital Biol 152:66–78PubMedGoogle Scholar
  3. Apergis-Schoute J, Iordanidou P, Faure C, Jego S, Schone C, Aitta-Aho T, Adamantidis A, Burdakov D (2015) Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits. J Neurosci 35:5435–5441CrossRefGoogle Scholar
  4. Astrand A, Bohlooly-Y M, Larsdotter S, Mahlapuu M, Andersén H, Tornell J, Ohlsson C, Snaith M, Morgan DG (2004) Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol 287:R749–R758CrossRefGoogle Scholar
  5. Blessing W, Mohammed M, Ootsuka Y (2013) Brown adipose tissue thermogenesis, the basic rest-activity cycle, meal initiation, and bodily homeostasis in rats. Physiol Behav 121:61–69CrossRefGoogle Scholar
  6. Bornkamp JL, Robertson S, Isaza NM, Harrison K, DiGangi BA, Pablo L (2016) Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy. Am J Vet Res 77:351–357CrossRefGoogle Scholar
  7. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW (2012) Control of sleep and wakefulness. Physiol Rev 92:1087–1187CrossRefGoogle Scholar
  8. Cabanac M (1996) The place of behavior in physiology. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology. Environmental physiology (section 4). Oxford University Press, Oxford, pp 1523–1536Google Scholar
  9. Cerri M (2017) The central control of energy expenditure: exploiting torpor for medical applications. Annu Rev Physiol 79:167–186CrossRefGoogle Scholar
  10. Cerri M, Luppi M, Tupone D, Zamboni G, Amici R (2017) REM sleep and endothermy: potential sites and mechanism of a reciprocal interference. Front Physiol 8:624CrossRefGoogle Scholar
  11. Clapham JC (2012) Central control of thermogenesis. Neuropharmacology 63:111–123CrossRefGoogle Scholar
  12. Clark-Price S (2015) Inadvertent perianesthetic hypothermia in small animal patients. Vet Clin North Am Small Anim Pract 45:983–994CrossRefGoogle Scholar
  13. Eban-Rothschild A, Giardino WJ, de Lecea L (2017) To sleep or not to sleep: neuronal and ecological insights. Curr Opin Neurobiol 44:132–138CrossRefGoogle Scholar
  14. Glick M, Segal-Lieberman G, Cohen R, Kronfeld-Schor N (2009) Chronic MCH infusion causes a decrease in energy expenditure and body temperature, and an increase in serum IGF-1 levels in mice. Endocrine 36:479–485CrossRefGoogle Scholar
  15. Grigg GC, Beard LA, Augee ML (2004) The evolution of endothermy and its diversity in mammals and birds. Physiol Biochem Zool 77:982–997CrossRefGoogle Scholar
  16. Ito M, Gomori A, Ishihara A, Oda Z, Mashiko S, Matsushita H, Yumoto M, Ito M, Sano H, Tokita S, Moriya M, Iwaasa H, Kanatani A (2004) Characterization of MCH-mediated obesity in mice. Am J Physiol Endocrinol Metab 284:E940–E945CrossRefGoogle Scholar
  17. Krauchi K (2007) The thermophysiological cascade leading to sleep initiation in relation to phase of entrainment. Sleep Med Rev 11:439–451CrossRefGoogle Scholar
  18. Kushikata T, Sawada M, Niwa H, Kudo T, Kudo M, Tonosaki M, Hirota K (2016) Ketamine and propofol have opposite effects on postanesthetic sleep architecture in rats: relevance to the endogenous sleep-wakefulness substances orexin and melanin-concentrating hormone. J Anesth 30:437–443CrossRefGoogle Scholar
  19. Lovegrove BG (2012) The evolution of endothermy in Cenozoic mammals: a plesiomorphic-apomorphic continuum. Biol Rev Camb Philos Soc 87:128–162CrossRefGoogle Scholar
  20. Luppi PH, Clément O, Fort P (2013) Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control. Curr Opin Neurobiol 23:786–792CrossRefGoogle Scholar
  21. Martelli D, Luppi M, Cerri M, Tupone D, Perez E, Zamboni G, Amici R (2012) Waking and sleeping following water deprivation in the rat. PLoS One 7:e46116CrossRefGoogle Scholar
  22. Monti JM, Torterolo P, Lagos P (2013) Melanin-concentrating hormone control of sleep-wake behavior. Sleep Med Rev 17:293–298CrossRefGoogle Scholar
  23. Morrison SF, Madden CJ, Tupone D (2014) Central neural regulation of brown adipose thermogenesis and energy expenditure. Cell Metab 19:741–756CrossRefGoogle Scholar
  24. Nespolo RF, Bacigalupe LD, Figueroa CC, Koteja P, Opazo JC (2011) Using new tools to solve an old problem: the evolution of endothermy in vertebrates. Trends Ecol Evol 26:414–423CrossRefGoogle Scholar
  25. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ (2002) The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110:515–526CrossRefGoogle Scholar
  26. Pereira-da-Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, Carvalheira JB, Ventrucci G, Marcondes MC, Cruz-Neto AP, Saad MJ, Boschero AC, Carneiro EM, Velloso LA (2003) Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 144:4831–4840CrossRefGoogle Scholar
  27. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek J, Kanarek R, Maratos-Flier E (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380:243–247CrossRefGoogle Scholar
  28. Saito Y, Cheng M, Leslie FM, Civelli O (2001) Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol 435:26–40CrossRefGoogle Scholar
  29. Satinoff E (1996) Behavioral thermoregulation in the cold. In: Fregly MJ, Blatteis CM (eds) Handbook of physiology. Environmental physiology (section 4). Oxford University Press, Oxford, pp 481–505Google Scholar
  30. Segal-Lieberman G, Bradley RL, Kokkotou E, Carlson M, Trombly DJ, Wang X, Bates S, Myers MG Jr, Flier JS, Maratos-Flier E (2003) Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A 100:10085–10090CrossRefGoogle Scholar
  31. Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Guan XM, MacNeil DJ, Kanatani A, Van der Ploeg LH, Howard AD (2002) Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 79:785–792CrossRefGoogle Scholar
  32. Tupone D, Madden CJ, Cano G, Morrison SF (2011) An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J Neurosci 31:15944–15955CrossRefGoogle Scholar
  33. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB (2016) Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience 336:102–113CrossRefGoogle Scholar
  34. Willmer P, Stone G, Johnston I (eds) (2000) Environmental physiology of animals. Blackwell Science, Oxford, pp 415–509Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor SciencesUniversity of BolognaBolognaItaly

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