Cannabinoids, Sleep, and the MCH System

  • Eric Murillo-RodríguezEmail author
  • Daniela Morales-Lara
  • José Carlos Pastrana-Trejo
  • Lorena Macías-Triana
  • Karen Romero-Cordero
  • Miriel de-la-Cruz
  • Clelia De-la-Peña


Marijuana is a colloquial name given to Cannabis sativa, which has been used for diverse purposes, including as a therapeutical element for multiple health issues. The neurobiological effects of C. sativa involve a complex biological machinery including receptors, named CB1 and CB2 cannabinoid receptors. These receptors recognize endogenous cannabinoid-like compounds, such as anandamide and 2-arachinonolglycerol which seems to display sleep-inducing properties. Along decades, the study of the putative role of exogenous and endogenous cannabinoids in sleep modulation has brought critical data. Since endocannabinoids have been described in sleep-related brain areas, intriguing issues regarding whether hypothalamic substrates, such as MHC, may be interacting with the endocannabinoids have been raised.


Cannabis sativa Cannabidiol Rapid eye movement sleep Melanin-concentrating hormone Hypothalamus 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Eric Murillo-Rodríguez
    • 1
    • 2
    • 3
    Email author
  • Daniela Morales-Lara
    • 1
    • 2
    • 3
  • José Carlos Pastrana-Trejo
    • 1
    • 2
    • 3
  • Lorena Macías-Triana
    • 1
    • 2
    • 3
  • Karen Romero-Cordero
    • 1
    • 2
    • 3
  • Miriel de-la-Cruz
    • 1
    • 2
    • 3
  • Clelia De-la-Peña
    • 4
  1. 1.Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la SaludUniversidad Anáhuac MayabMéridaMexico
  2. 2.Grupo de Investigación en Envejecimiento, División Ciencias de la SaludUniversidad Anáhuac MayabMéridaMexico
  3. 3.Intercontinental Neuroscience Research GroupMéridaMexico
  4. 4.Centro de Investigación Científica de Yucatán. A.CUnidad de BiotecnologíaMéridaMexico

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