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Garlic Preventive Effect on Cancer Development

  • Mostafa I. Waly
  • Mohammad Shafiur Rahman
Chapter

Abstract

Today, millions of people are living with cancer or have had cancer. The risk of developing most types of cancer can be reduced by changes in a person’s lifestyle or by adopting primary intervention strategies. Often, the sooner a cancer is found and treatment begins, the better are the chances for living for many years. Cancer is a disorder of cell proliferation and it is the leading global cause of death. Cancer research has traditionally focused on allocating bioactive components for the cancer prevention by eliminating cancerous cells and cellular carcinogenesis metabolites. Carcinogenesis is a multistage process that is distinguished with two steps; the first step is called initiation that occurs when cells are exposed to cancer-producing agents, which damage the cell’s deoxynucleic acid. The second step is called promotion which occurs when the cancerous cells divided subsequently, and this post ignition step is characterized by neoplasia and DNA adducts formation. Cancer morbidity and mortality afflicts both genders, and at a global level, there are about 945,000 new cancer cases and 620,000.

References

  1. 1.
    Sultana S, Asif HM, Nazar HMI, Akhtar N, Rehman JU, Rehman RU. Medicinal plants combating against cancer—a green anticancer approach. Asian Pac J Cancer Prev. 2014;15(11):4385–94.CrossRefPubMedGoogle Scholar
  2. 2.
    Turati F, Pelucchi C, Guercio V, La Vecchia C, Galeone C. Allium vegetable intake and gastric cancer: a case-control study and meta-analysis. Mol Nutr Food Res. 2015;59(1):171–9.CrossRefPubMedGoogle Scholar
  3. 3.
    Lazarevic K, Nagorni A, Rancic N, Milutinovic S, Stosic L, Ilijev I. Dietary factors and gastric cancer risk: hospital-based case control study. J BUON. 2010;15(1):89–93.PubMedGoogle Scholar
  4. 4.
    Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD. Vegetables, fruit, and colon cancer in the Iowa Women’s Health Study. Am J Epidemiol. 1994;139(1):1–15.CrossRefPubMedGoogle Scholar
  5. 5.
    Nelson SM, Gao YT, Nogueira LM, Shen MC, Wang B, Rashid A, Hsing AW, Koshiol J. Diet and biliary tract cancer risk in Shanghai, China. PLoS One. 2017;12(3):e0173935.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Zhou XF, Ding ZS, Liu NB. Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects. Asian Pac J Cancer Prev. 2013;14(7):4131–4.CrossRefPubMedGoogle Scholar
  7. 7.
    Kim JY, Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims. Am J Clin Nutr. 2009;89(1):257–64.CrossRefPubMedGoogle Scholar
  8. 8.
    Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M. Diallyl trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway. J Cell Biochem. 2017.  https://doi.org/10.1002/jcb.26613.
  9. 9.
    Saini V, Manral A, Arora R, Meena P, Gusain S, Saluja D, Tiwari M. Novel synthetic analogs of diallyl disulfide triggers cell cycle arrest and apoptosis via ROS generation in MIA PaCa-2 cells. Pharmacol Rep. 2017;69(4):813–21.CrossRefPubMedGoogle Scholar
  10. 10.
    Yin X, Feng C, Han L, Zhang Y, Zhang J. Diallyl disulfide inhibits the metastasis of type II esophageal-gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways in vitro. Oncol Rep. 2018;39(2):784–94.PubMedGoogle Scholar
  11. 11.
    Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anti Cancer Agents Med Chem. 2011;11(3):249–53.CrossRefGoogle Scholar
  12. 12.
    Petropoulos S, Di Gioia F, Vegetable Organosulfur NG. Compounds and their health promoting effects. Curr Pharm Des. 2017;23(19):2850–75.CrossRefPubMedGoogle Scholar
  13. 13.
    Roseblade A, Ung A, Bebawy M. Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer. Acta Pharmacol Sin. 2017;38(10):1353–68.CrossRefPubMedGoogle Scholar
  14. 14.
    Zhang X, Zhu Y, Duan W, Feng C, He X. Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway. Mol Med Rep. 2015;11(4):2755–60.CrossRefPubMedGoogle Scholar
  15. 15.
    Yang C, Chen L, Xu S, Day JJ, Li X, Xian M. Recent development of hydrogen sulfide releasing/stimulating reagents and their potential applications in cancer and glycometabolic disorders. Front Pharmacol. 2017;8:664.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006;136(Suppl. 3):716S–25S.CrossRefPubMedGoogle Scholar
  17. 17.
    Zhu X, Jiang X, Li A, Sun Y, Liu Y, Sun X, Feng X, Li S, Zhao Z. S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways. Biochem Biophys Res Commun. 2017;491(3):821–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Xiao D, Pinto JT, Gundersen GG, Weinstein IB. Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells. Mol Cancer Ther. 2005;4(9):1388–98.CrossRefPubMedGoogle Scholar
  19. 19.
    Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res. 2003;63(20):6825–37.PubMedGoogle Scholar
  20. 20.
    Park JM, Han YM, Kangwan N, Lee SY, Jung MK, Kim EH, Hahm KB. S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histonedeacetylation inhibition. J Gastroenterol Hepatol. 2014;29(Suppl 4):80–92.CrossRefPubMedGoogle Scholar
  21. 21.
    Cho O, Hwang HS, Lee BS, Oh YT, Kim CH, Chun M. Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor. Radiat Oncol J. 2015;33(4):328–36.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Xu YS, Feng JG, Zhang D, Zhang B, Luo M, Su D, Lin NM. S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro. Acta Pharmacol Sin. 2014;35(2):267–74.CrossRefPubMedGoogle Scholar
  23. 23.
    Shirin H, Pinto JT, Kawabata Y, Soh JW, Delohery T, Moss SF, Murty V, Rivlin RS, Holt PR, Weinstein IB. Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res. 2001;61(2):725–31.PubMedGoogle Scholar
  24. 24.
    Liu Y, Yan J, Han X, Hu W. Garlic-derived compound S-allylmercaptocysteine (SAMC) is active against anaplastic thyroid cancer cell line 8305C (HPACC). Technol Health Care. 2015;23(Suppl 1):S89–93.CrossRefPubMedGoogle Scholar
  25. 25.
    Yan JY, Tian FM, Hu WN, Zhang JH, Cai HF, Li N. Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). Eur Rev Med Pharmacol Sci. 2013;17(6):745–51.PubMedGoogle Scholar
  26. 26.
    Jurkowska H, Wrobel M, Kaczor-Kaminska M, Jasek-Gajda E. A possible mechanism of inhibition of U87MG and SH-SY5Y cancer cell proliferation by diallyl trisulfide and other aspects of its activity. Amino Acids. 2017;49:1855–66.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Talib WH. Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition. 2017;43–44:89–97.CrossRefPubMedGoogle Scholar
  28. 28.
    Wei Z, Shan Y, Tao L, Liu Y, Zhu Z, Liu Z, Wu Y, Chen W, Wang A, Lu Y. Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis. Mol Carcinog. 2017;56:2317–31.CrossRefPubMedGoogle Scholar
  29. 29.
    Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ. Allicin: chemistry and biological properties. Molecules. 2014;19(8):12591–618.CrossRefPubMedGoogle Scholar
  30. 30.
    Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014;65(1):1–8.PubMedGoogle Scholar
  31. 31.
    Chen LY, Chen Q, Zhu XJ, Kong DS, Wu L, Shao JJ, Zheng SZ. Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism. Int Immunopharmacol. 2016;36:23–30.CrossRefPubMedGoogle Scholar
  32. 32.
    Locatelli DA, Nazareno MA, Fusari CM, Camargo AB. Cooked garlic and antioxidant activity: correlation with organosulfur compound composition. Food Chem. 2017;220:219–24.CrossRefPubMedGoogle Scholar
  33. 33.
    Zeng Y, Li Y, Yang J, Pu X, Du J, Yang X, Yang T, Yang S. Therapeutic role of functional components in alliums for preventive chronic disease in human being. Evid Based Complement Alternat Med. 2017;2017:9402849.PubMedPubMedCentralGoogle Scholar
  34. 34.
    Beretta HV, Bannoud F, Insani M, Berli F, Hirschegger P, Galmarini CR, Cavagnaro PF. Relationships between bioactive compound content and the antiplatelet and antioxidant activities of six allium vegetable species. Food Technol Biotechnol. 2017;55(2):266–75.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mostafa I. Waly
    • 1
  • Mohammad Shafiur Rahman
    • 1
  1. 1.Department of Food Science and NutritionCollege of Agricultural and Marine Sciencesm, Sultan Qaboos UniversityMuscatOman

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