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Stem Cell-Based RPE Therapy for Retinal Diseases: Engineering 3D Tissues Amenable for Regenerative Medicine

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1074))

Abstract

Recent clinical trials based on human pluripotent stem cell-derived retinal pigment epithelium cells (hPSC-RPE cells) were clearly a success regarding safety outcomes. However the delivery strategy of a cell suspension, while being a smart implementation of a cell therapy, might not be sufficient to achieve the best results. More complex reconstructed tissue formulations are required, both to improve functionality and to target pathological conditions with altered Bruch’s membrane like age-related macular degeneration (AMD). Herein, we describe the various options regarding the stem cell source choices and the different strategies elaborated in the recent years to develop engineered RPE sheets amenable for regenerative therapies.

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Acknowledgments

I-Stem is supported by the AFM-Téléthon. This work was supported by grants from the Fondation pour la Recherche Medicale (Bio-engineering program - DBS20140930777), the LABEX REVIVE (ANR-10-LABX-73), NeurATRIS ​(Investissements d'Avenir - ANR-11-INBS-0011), INGESTEM: the National Infrastructure Engineering for Pluripotent and differentiated Stem cells (Investissements d'Avenir - ANR-11-INBS-000).

Author information

Authors and Affiliations

  1. INSERM UMR861, I-Stem, AFM, Corbeil-Essonnes, France

    Karim Ben M’Barek, Walter Habeler & Christelle Monville

  2. UEVE UMR861, I-Stem, AFM, Corbeil-Essonnes, France

    Karim Ben M’Barek, Walter Habeler & Christelle Monville

  3. CECS-I-Stem, AFM, Corbeil-Essonnes, France

    Karim Ben M’Barek & Walter Habeler

Authors
  1. Karim Ben M’Barek
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  2. Walter Habeler
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  3. Christelle Monville
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Corresponding author

Correspondence to Christelle Monville .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. Ophthalmology and Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  3. School of Medicine Beckman Vision Center, University of California San Francisco, San Francisco, California, USA

    Matthew M. LaVail

  4. Departments of Ophthalmology and Cell Biology, Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

  5. Division of Ophthalmology, Case Western Reserve University, Cleveland, Ohio, USA

    Joe G. Hollyfield

  6. Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

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Ben M’Barek, K., Habeler, W., Monville, C. (2018). Stem Cell-Based RPE Therapy for Retinal Diseases: Engineering 3D Tissues Amenable for Regenerative Medicine. In: Ash, J., Anderson, R., LaVail, M., Bowes Rickman, C., Hollyfield, J., Grimm, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 1074. Springer, Cham. https://doi.org/10.1007/978-3-319-75402-4_76

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