Posttransplant Lymphoproliferative Disorder
Posttransplant lymphoproliferative disorder (PTLD) is a common malignancy arising after solid organ transplantation. Clinical features are nonspecific and imaging plays an important role in the diagnosis. The location of disease is dependent on the type of organ transplantation although, generally, the transplanted organ itself is commonly affected. Extra-nodal disease is more common than nodal disease, and aside from the transplanted organ, the bowel and central nervous system (CNS) are frequently affected organs. Solitary or multifocal hypo-enhancing masses are often seen with solid organ involvement, though an infiltrating mass is also encountered. Bowel wall thickening with aneurysmal dilation is a classic finding in small bowel PTLD. Multiple pulmonary nodules are the most common appearance of thoracic PTLD, and single or multiple enhancing brain masses are seen with CNS involvement. This chapter will discuss the imaging appearances of PTLD throughout the body.
KeywordsPosttransplant lymphoproliferative disorder PTLD Lymphoma Solid organ transplantation CT Ultrasound PET/CT MRI
- 30.Cavaliere R, Petroni G, Lopes MB, Schiff D, International Primary Central Nervous System Lymphoma Collaborative Group. Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Cancer. 2010;116(4):863–70.CrossRefPubMedCentralPubMedGoogle Scholar