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Bone and Diabetes

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Multidisciplinary Approach to Osteoporosis

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Abstract

Diabetes is a metabolic disease characterized by high blood glucose levels resulting from impaired insulin production or insulin resistance or both. It has been well established that bone fragility is a new complication of diabetes, particularly of type 1 diabetes (T1D) [1]. Diabetes may negatively affect bone health by unbalancing several processes and systems: bone formation, bone resorption, collagen formation and collagen cross-linking, secretion of inflammatory cytokines, skeletal muscle, incretin system, bone marrow adiposity, calcium metabolism, etc.

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Authors and Affiliations

  1. Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

    Andrea Palermo, Anda Mihaela Naciu, Gaia Tabacco & Nicola Napoli

  2. Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy

    Luca D’Onofrio

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  1. Andrea Palermo
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  1. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Andrea Lenzi

  2. Department of Movement, Human and Health Sciences, Foro Italico University of Rome, Rome, Italy

    Silvia Migliaccio

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Palermo, A., Naciu, A.M., Tabacco, G., D’Onofrio, L., Napoli, N. (2018). Bone and Diabetes. In: Lenzi, A., Migliaccio, S. (eds) Multidisciplinary Approach to Osteoporosis. Springer, Cham. https://doi.org/10.1007/978-3-319-75110-8_10

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