Abstract
Grayscale ultrasound (US) is the principal ultrasound imaging modality to diagnose breast diseases and breast cancer in particular. Nodular type of breast cancer (up to 80% of breast carcinoma) is characterized by the presence of a lesion within breast structure that can be revealed in grayscale mode or other US regimens. Infiltrative (diffuse) types of breast cancer usually exhibit clinically evident local signs. Ultrasound is highly sensitive (85–93%) in detection of a tumor in any clinically doubtful situation and can provide guidance for biopsy with morphological verification. Paget’s cancer is an intraductal epidermotropic eczema-like breast cancer, which originates from the ostia of large milk ducts of the nipple and involves the nipple and the areola and spreads to other parts of the breast. Assessment of the elasticity (stiffness) of tissues for early diagnosis and differentiation of malignant breast conditions is undoubtedly promising and prospective. Contrast-enhanced ultrasound (CEUS) is an informative technology for visualization of the blood flow in breast tumors and identification of neoangiogenesis, which is a characteristic for malignancy. The sensitivity of CEUS in the detection of breast cancer in women is 88%, specificity 90%, and accuracy 89%. Different classifications of breast cancer, including breast imaging-reporting and data system (BI-RADS), morphological types of tumors, and ultrasound correlations are also provided.
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Borsukov AV, Amosov VN, Bus’ko EA et al (2016) Guidelines 2016 on standardized method of compression elastography of the mammary gland, the thyroid gland, regional lymph nodes, extraorgan lesions and in endosonography. Smolensk (Book in Russian)
Ciatto S, Rosselli del Turco M, Catarzi S et al (1994) The diagnostic role of breast echography. Radiol Med Torino 88(3):221–224
Cosgrove DO, Bamber JC, Davey YB et al (1990) Color doppler signals from breast tumors. Radiology 176:175–180
Cosgrove DO, Kedar RP, Bamber JC et al (1993) Breast diseases: color Doppler US in differential diagnosis. Radiology 189(1):99–104
De Albertis P, Oliveri M, Quadri P et al (1995) Retrospective analysis of color Doppler ultrasonography and flowmetry findings in solid nodular pathology of the breast. Radiol Med 89(1–2):28–35. (Article in Italian)
Evans A, Whelehan P, Thomson K et al (2010) Quantitative shear wave ultrasound elastography: initial experience in solid breast masses. Breast Cancer Res 12(6):R104
Fiedler V, Neubauer KD, Schneiders A, Herzig P (1996) Ranking of color-coded duplex ultrasonography (CCDU) in the staging of breast tumors. RöFo 165(2):159–165. (Article in German)
Fisenko EP (1999) Ultrasound diagnosis of tumoral lesions of the breast in surgical clinic. PhD thesis. Moscow (Book in Russian)
Fisenko EP, Sandrikov VA (1998) Results of complex ultrasound examination of breast lesions. Ultrazvukivaya Diagnostica 3:39–43. (Article in Russian)
Folkman J (1995) Tumor, angiogenesis. J Adv Cancer Res 43:175–200
Gromov AI, Kubova SY (2004) Possibilities of use of twinkling-artifact at calcifications of various organs. Materials of the 1st Conference “Radiological diagnosis and therapy in clinical medicine”, Moscow, pp 35–36. (Article in Russian)
Harchenko VP, Rozhkova NI, Zubovsky GA, Medvedeva NA (1993) A method of color dopplerography in the diagnosis of breast diseases. Visualizaciya v Clinicke 1(3):33–43. (Article in Russian)
Harchenko VP, Rozhkova NI, Frolov IM (1999) Interventional examination procedures in breast diseases. Vestnik Roentgenologii i Radiologii 3:26–30. (Article in Russian)
Haylenko VA, Komova DV, Bogatiryov VN (2005) Diagnosis of breast cancer. Medical Information Agency, Moscow. (Book in Russian)
Holcombe C, Pugh N, Lyons K et al (1995) Blood flow in breast cancer and fibroadenoma estimated by colour Doppler ultrasonography. Br J Surg 82(6):787–788
Kolesnik AY, Shershneva MA, Meskih EV et al (2014) New approaches to the diagnostic algorithm of odematous-infiltrative type of breast cancer (literature review). Medicinskaya Visualizaciya 5:124–129. (Article in Russian)
Komarova LE (2006) Mammographic screening and its role in decrease of mortality from breast cancer. Mammologiya 6:5–10. (Article in Russian)
Korzhenkova GP (2004) Complex X-ray and sonographic diagnosis of breast diseases. Strom, Moscow. (Book in Russian)
Lee SK, Lee I, Lee KR et al (1995) Evaluation of breast tumors with color Doppler imaging: a comparison with image directed Doppler ultrasound. Clin Ultrasound 23:367–373
Lelyuk VG, Lelyuk SE (2007) Ultrasound angiology. Realnoye Vremya, Moscow. (Book in Russian)
Madjar H, Prompeler HJ, Sauerbrei W et al (1995) Differential diagnosis of breast lesions by color Doppler. Ultrasound Obstet Gynecol 6(3):199–204
Marquet KL, Funk A, Handt S et al (1995) Displacement margins and edge contour: informative criteria of tumor dignity in ultrasound mammography. Geburtshilfe Frauenheilkd 55:548–552
Mihaylov SA, Skrynnik EB (1997) Influence of histological structure of tumors on the value of ultrasound diagnosis of breast neoplasms. Materials of the Conference “Modern radiological diagnostics and therapy”, Chelyabinsk, pp 131–132. (Article in Russian)
Mitkov VV, Huako SA, Ampilogova ER, Mitkova MD (2011) Assessment of reproducibility of the results of quantitative ultrasound elastography. Ultrazvukovaya i Functionalnaya Diagnostica 2:115–121. (Article in Russian)
Mitkov VV, Chubarova KA, Zabolotskaya NV, Mitkova MD (2013) Possobilities of share-wave elastography in differential diagnosis of focal types of malignant and benign breast tumors. Ultrazvukovaya i Functionalnaya Diagnostica 6:27–38. (Article in Russian)
Mitkov VV, Chubarova KA, Zabolotskaya NV et al (2014) Value of share-wave elastography in the diagnosis of breast cancer. Ultrazvukovaya i Functionalnaya Diagnostica 1:11–24. (Article in Russian)
Mitkov VV, Chubarova KA, Zabolotskaya NV et al (2015) Share-wave elastography in multiparametric ultrasound diagnostics of various size malignant tumors of mammary glands. Ultrazvukovaya i Functionalnaya Diagnostica 2:9–18. (Article in Russian)
Piscaglia F, Salvatore V, Di Donato R et al (2011) Accuracy of virtual touch acoustic radiation force impulse (ARFI) imaging for the diagnosis of cirrhosis during liver ultrasonography. Ultraschall Med 32(2):167–175
Possover M, Morawski A, Muller E, Hettenbach A (1994) New perspectives in color ultrasound in breast diagnosis. Geburtshilfe Frauenheilkd 54(8):432–436
Postnova NM, Vasilyev AY, Zykin BI et al (2011) Possibilities of sonoelastography of shift wave in differential diagnosis of breast diseases. Diagn Interv Radiol 5(2):324–325. (Article in Russian)
Rozhkova NI (1993) X-ray diagnosis of breast diseases. Medicina, Moscow. (Book in Russian)
Rozhkova NI, Zubarev AV, Zapirova SB, Churkina SO, Hohlova EA (2010) New technology—sonoelastography in mammology. Medicinskaya Visualizaciya 4:89–99. (Article in Russian)
Rozhkova NI, Hohlova EA, Zubarev AV, Budanov MV (2011) Possibilities of new ultrasound technology—sonoelastography—in the diagnosis of benign and malignant breast diseases. Luchevaya diagnostic i therapiya 2:56–68. (Article in Russian)
Sandrikov VA, Fisenko EP (1998) Assessment of blood flow velosities in breast vessels at its tumoral pathology. Vestnik Rossiyskoy, Academii Medicinskih nauk, pp 49–52. (Article in Russian)
Sencha AN, Sergeeva ED, Shmelev DM (2009) Sonoelastography in complex diagnosis of breast lesions. Ultrazvukovaya i Functionalnaya Diagnostica 4:99. (Article in Russian)
Sencha AN, Evseeva EV, Petrovsky DA et al (2011) Methods of ultrasound examination in diagnosis of breast cancer. Vidar, Moscow. (Book in Russian)
Sencha AN, Evseeva EV, Mogutov MS, Patrunov YN (2013) Breast ultrasound. Springer, Berlin, Heidelberg
Sencha AN, Mogutov MS, Patrunov YN et al (2015) Ultrasound examination with use of contrast agents. Vidar-M, Moscow. (Book in Russian)
Shevchenko EP (1999) Color Doppler mapping in examination of breast neoplasms. SonoAce International 4:72–76. (Article in Russian)
Sinyukova GT, Korzhenkova GP, Danzanova TY (2007) Ultrasound examination of breasts in oncology. Strom, Moscow. (Book in Russian)
Smirnova NA (1995) Possibilities color doppler in complex diagnosis of breast diseases. PhD thesis. Moscow (Book in Russian)
Sobin LH, Gospodarowicz MK, Wittekind CH (eds) (2010) International Union against Cancer. TNM classification of malignant tumours. 7th ed. Chichester, West Sussex, UK; Hoboken, NJ: Wiley
Sohn C, Thiel C, Bandendistel A et al (1997) Degree of blood supply defined by ultrasound new prognostic factor? Mammoligy 2:7–10
Svensson WE (1997) A review of the current status of breast ultrasound. Eur J Ultrasound 6(2):77–101
Tavassoéli FA, Devilee P (eds) (2003) World Health Organization: Tumours of the Breast and Female Genital Organs (Who/IARC Classification of Tumours) (IARC WHO Classification of Tumours)
Trofimova EY (2000) Ultrasound dopplerography in breast cancer. Ultrazvukovaya Diagnostica 2:26–29. (Article in Russian)
Trofimova EY (2002) Ultrasound diagnosis of breast diseases. Visualizaciya v Clinicke 6:44–50. (Article in Russian)
Trufanov GE, Ryazanov VV, Ivanov LI (2009) Ultrasound in mammology. ELBI-S-pb, Saint Petersburg. (Book in Russian)
Ueno E (1996) Breast ultrasound. Gan To Kagaku Ryoho 23(1):14–23
Vetshev PS, Smiths NS, Beltsevich DG, Ozerov SK (1997) Possibilities of US examination in differential diagnosis of benign lesions and breast cancer. Surgery 6:25–27. (Article in Russian)
Wild JJ, Neal D (1951) Use of high-frequency ultrasonic waves for detecting changes of texture in living tissues. Lancet 6656(1):655–657
Wild JJ, Reid JM (1952) Further pilot echographic studies on the histologic structure of tumors of the living intact human breast. Am J Pathol 28(5):839–861
Yang WT, Ahuja AT, Tang A et al (1996) High frequency ultrasound detection of axillary lymph node metastases in breast cancer. J Ultrasound Med 15(3):241–246
Youssefzadeh S, Eibenberger K, Helbich T et al (1996) Use of resistance index for the diagnosis of breast tumors. Clin Radiol 51(6):418–420
Zabolotskaya NV, Zabolotsky VS (1997) Ultrasound mammography. Strom, Moscow. (Book in Russian)
Zabolotskaya NV, Zabolotsky VS (2000) Complex ultrasound examination of breasts. Sonoace International 6:86–92. (Article in Russian)
Zabolotskaya NV, Zabolotsky VS (2005) New technologies in ultrasound mammography. Strom, Moscow. (Book in Russian)
Zhang Y, Jiang Q, Zhang Y et al (2013) Diagnostic value of contrast-enhanced ultrasound parametric imaging in breast tumors. J Breast Cancer 16(2):208–213
Zubarev AV (2009) Elastography—an innovative method of the search of cancers of various localizations. Polyclinica 4:32–37. (Article in Russian)
Zabolotskaya NV, Zabolotsky VS (1997) Ultrasound mammography. Strom, Moscow. (Book in Russian)
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Sencha, A.N., Patrunov, Y., Sencha, E., Penyaeva, E., Rodionov, V. (2018). Multiparametric Examination: Basic and Innovative Methods of Ultrasound in Diagnosis of Breast Cancer. In: Sukhikh, G., Sencha, A. (eds) Multiparametric Ultrasound Diagnosis of Breast Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-75034-7_6
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