Local Treatment of Brain Tumors and the Blood-Brain Barrier

  • Lenka Rajsiglova
  • Luca VannucciEmail author


Since the half of the past century, attempts to locally treat intracranial neoplasms have grown. From pioneering interstitial seeds of various materials (radioactive, non-radioactive) with or without the application of ElectroMagnetic Field (EMF), recently new interest was elicited by the possibilities offered by the nanotechnologies. The blocking activity of the Blood-Brain Barrier (BBB) represents main problem for every treatment of brain neoplasms. Shortly, here we summarize some aspects of the blood-brain barrier problem in the perspective of more efficient therapeutic approaches, like the use of nanoparticle and their theranostic possibilities.



The Authors thank the grants RVO 61388971, MSMT COST CZ LD 15135, UniCredit Bank CZ, Iginio Longo, Tristano Testa and CAMIC CZ Fund. This work was developed in the framework of COST Action MiMed TD1301 WG2.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Czech Academy of SciencesPragueCzech Republic

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