Systems Biology and Metabolic Modeling of C1-Metabolism

  • Ilya R. Akberdin
  • Merlin Thompson
  • Marina G. KalyuzhnayaEmail author


Recent developments in experimental technologies have transformed traditional microbial physiology into a data-rich or -omics discipline. As a result, it has caused a renaissance of the mathematical analysis of biological systems and stimulated the development of systems biology workflows which aim to provide a holistic vision of all cellular functions through genomics, transcriptomics, proteomics, metabolomics, and fluxomic data. In silico modeling of metabolic systems has become a powerful tool, providing insight into the complex processes in cellular metabolism and their underlying regulatory mechanisms, as well as potentially improving the biotechnological design of microbial strains with desired properties. In this chapter, we provide an overview of the systems biology of methane utilization, as an example of one unique microbial function that has been dissected using - omics technologies. We discuss the most recent advances in large-scale investigation and computational representation of related metabolic networks as well as highlight some challenges for further developments in the field.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ilya R. Akberdin
    • 1
  • Merlin Thompson
    • 1
  • Marina G. Kalyuzhnaya
    • 1
    • 2
    Email author
  1. 1.Department of BiologySan Diego State UniversitySan DiegoUSA
  2. 2.Viral Information InstituteSan Diego State UniversitySan DiegoUSA

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