Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will ~ A Proposal of “Body-Mind Integrative Science”

  • Yoriko AtomiEmail author
  • Miho Shimizu
  • Eri Ohto-Fujita
  • Aya Atomi
  • Saaya Hayasaki
  • Yoshikazu Higashi
  • Tomoaki Atomi
Part of the Heat Shock Proteins book series (HESP, volume 13)


The importance of small heat shock protein HSP in geroscience is increasing. We believe that research progress from life science should contribute to well-being. Molecular chaperone studies are considered superior when performed on model substrates and model animals. However, by itself, concrete measures for extending the healthy life of human beings are not provided. It is important to analyze the cell-animal-human results, interpret the relationship, and promote comprehensively studied HSP research. αB-crystallin (CRYAB) was identified for key molecule to explain the mechanism of exercise adaptation of slow-twitch muscle for a long ago. It is only human beings that stand up against gravity and move all day in their standing position. With CRYAB and tubulin/microtubule as a key word, we will introduce the principle of clarifying not only cells but also how to control the human body. Mechanistically fiber structure produced after protein assembly has not only multifunction but also is available as materials to make “body” and can sustain body weight by tension development at both micro- and macro-levels. This links cell’s autonomous regulating ability and human will to keep standing. This manuscript may contribute to develop a new direction of HSP Geroscience research proposing real program to healthy aging and mature human world.


αB-Crystallin (CRYAB) Cytoskeleton Dynamic Instability Heat Shock Protein Mechanical Stress Bipedal standing 





Extracellular matrix


Fluorescence recovery after photobleaching


Fluorescence resonance energy transfer


Heat shock protein


Heat shock protein family


Microtubule-associated protein





The works described here were partially supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Research grant from Japan Space Utilization Promotion Center, and Research grant from Japan Space Forum.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Yoriko Atomi
    • 1
    Email author
  • Miho Shimizu
    • 1
  • Eri Ohto-Fujita
    • 1
  • Aya Atomi
    • 1
  • Saaya Hayasaki
    • 1
  • Yoshikazu Higashi
    • 1
  • Tomoaki Atomi
    • 2
  1. 1.Material Health Science LaboratoryTokyo University of Agriculture and TechnologyTokyoJapan
  2. 2.Faculty of Health Sciences, Department of Physical TherapyKyorin UniversityTokyoJapan

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