Cognitive Enhancers

  • William James DeardorffEmail author
  • George T. Grossberg


Cognitive impairment is a common presenting symptom in a variety of neurologic conditions. This chapter follows the case of a patient who reports a mild decline in cognitive functioning, which gradually progresses to impairments across multiple cognitive domains and interference with daily activities. Treatment options across the spectrum from a mild neurocognitive disorder to the terminal stage of Alzheimer’s disease are discussed. Recommendations regarding treatment initiation with cholinesterase inhibitors, dose titration, combination therapy with memantine, treatment discontinuation, and management of side effects are presented. The role of other therapeutic interventions, such as vitamins, dietary supplements, and lifestyle-based interventions, is also discussed. Finally, a brief survey of the treatment of cognitive impairment in other neurologic disorders, such as multiple sclerosis and Parkinson’s disease dementia, is provided.


Alzheimer’s disease Cholinesterase inhibitors Cognitive enhancers Cognitive impairment Dementia Memantine Neurocognitive disorder 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • William James Deardorff
    • 1
    Email author
  • George T. Grossberg
    • 2
  1. 1.Department of Psychiatry and Behavioral NeuroscienceSaint Louis University School of MedicineSt. LouisUSA
  2. 2.Division of Geriatric Psychiatry, Department of Psychiatry & Behavioral NeuroscienceSt. Louis University School of MedicineSt. LouisUSA

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