Temporal Bone Malignancies in Children
Temporal bone malignancies in children often present with signs and symptoms often associated with more common pediatric ear symptoms. Ear pain, ear drainage, and hearing loss may be present in these tumors, but when present, signs such as cranial nerve deficits and masses are particularly worrisome. Imaging including CT and MRI is important to determine extent of tumor and to give some clues as to the nature of the mass. Biopsy is often required. Common temporal bone malignancies include rhabdomyosarcoma and Langerhans cell histiocytosis. Osteosarcoma, Ewing’s sarcoma, and malignancies of the lymphoreticular system should also be considered. A combination of chemotherapy, radiation, and surgery forms the treatment plan for these malignancies. Due to the common pathologies encountered in the pediatric population, the role of surgery is usually for biopsy of the lesion or in the treatment of residual tumor after chemotherapy and radiation. Primary surgical therapy is appropriate in some cases.
KeywordsRhabdomyosarcoma Langerhans histiocytosis Ewing’s sarcoma Osteosarcoma Chondrosarcoma Radiation-associated malignancy Pediatric Temporal bone cancer Acute leukemia Late effects of treatment Chemotherapy
- 3.Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer. 1995;75(8):2186–95. https://doi.org/10.1002/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-F.CrossRefPubMedGoogle Scholar
- 4.Maurer HM, Gehan EA, Beltangady M, et al. The intergroup rhabdomyosarcoma study-II. Cancer. 1993;71(5):1904–22. https://doi.org/10.1002/1097-0142(19930301)71:5<1904::AID-CNCR2820710530>3.0.CO;2-X.CrossRefPubMedGoogle Scholar
- 10.Hawkins DS, Anderson JR, Paidas CN, et al. Improved outcome for patients with middle ear rhabdomyosarcoma: a children’s oncology group study. J Clin Oncol. 19(12):3073–9. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med4&AN=11408504.PubMedGoogle Scholar
- 15.Goudarzipour K, Shamsian S, Alavi S, Nourbakhsh K, Aghakhani R, Eydian Z, Arzanian MT. Primary Ewing’s sarcoma of the temporal bone in an infant. Int J Hematol Stem Cell Res. 2015;9(2):104.Google Scholar