Advertisement

Unusual Tumors of the Middle Ear

  • Paul W. Gidley
Chapter

Abstract

Middle ear tumors are more uncommon than ear canal tumors. Often, these tumors present as conductive hearing loss or as chronic otitis media. This chapter reviews the tumors that occur in the middle ear, excepting squamous cell carcinoma. The pathologic nomenclature has evolved over time. Middle ear adenomatous neoplasms, neuroendocrine adenomatous middle ear neoplasm, and carcinoid tumors are grouped under the same heading. Inverting papilloma, Schneiderian papilloma, and Schneiderian carcinoma are considered as a spectrum of a single clinical entity. Middle ear adenocarcinoma, lymphoepithelial-like carcinoma, and aggressive papillary tumor of the middle ear are also discussed.

Keywords

Middle ear adenomatous neoplasms Neuroendocrine adenomatous middle ear neoplasm Middle ear carcinoid tumor Inverting papilloma Schneiderian papilloma Schneiderian carcinoma Middle ear adenocarcinoma Lymphoepithelial-like carcinoma Aggressive papillary tumor 

References

  1. 1.
    Gurgel RK, Karnell LH, Hansen MR. Middle ear cancer: a population-based study. Laryngoscope. 2009;119(10):1913–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Dadas B, Alkan S, Turgut S, Basak T. Primary papillary adenocarcinoma confined to the middle ear and mastoid. Eur Arch Otorhinolaryngol. 2001;258(2):93–5.PubMedCrossRefGoogle Scholar
  3. 3.
    Duderstadt M, Forster C, Welkoborsky HJ, Ostertag H. Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions. Eur Arch Otorhinolaryngol. 2012;269(3):823–31.PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Bell D, El-Naggar AK, Gidley PW. Middle ear adenomatous neuroendocrine tumors: a 25-year experience at MD Anderson Cancer Center. Virchows Arch. 2017;471(5):667–72.PubMedCrossRefGoogle Scholar
  5. 5.
    Derlacki EL, Barney PL. Adenomatous tumors of the middle ear and mastoid. Laryngoscope. 1976;86(8):1123–35.PubMedCrossRefGoogle Scholar
  6. 6.
    Almuhanna K. Neuroendocrine adenoma of the middle ear with the history of otitis media and carcinoma of the cheek: a case report. BMC Res Notes. 2014;7:532.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Torske KR, Thompson LD. Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol. 2002;15(5):543–55.PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Ramsey MJ, Nadol JB Jr, Pilch BZ, McKenna MJ. Carcinoid tumor of the middle ear: clinical features, recurrences, and metastases. Laryngoscope. 2005;115(9):1660–6.PubMedCrossRefGoogle Scholar
  9. 9.
    Gulya AJ, Glasscock ME, Pensak ML. Primary adenocarcinoma of the temporal bone with posterior fossa extension: case report. Laryngoscope. 1986;96(6):675-7.PubMedCrossRefGoogle Scholar
  10. 10.
    Eden AR, Pincus RL, Parisier SC, Som PM. Primary adenomatous neoplasm of the middle ear. Laryngoscope. 1984;94(1):63–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Goebel JA, Smith PG, Kemink JL, Graham MD. Primary adenocarcinoma of the temporal bone mimicking paragangliomas: radiographic and clinical recognition. Otolaryngol Head Neck Surg. 1987;96(3):231–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Chan KC, CM W, Huang SF. Carcinoid tumor of the middle ear: a case report. Am J Otolaryngol. 2005;26(1):57–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Ouaz K, Robier A, Lescanne E, Bobillier C, Moriniere S, Bakhos D. Cancer of the external auditory canal. Eur Ann Otorhinolaryngol Head Neck Dis. 2013;130(4):175–82.CrossRefGoogle Scholar
  14. 14.
    Ferri E, Cavaleri S, Ianniello F, Longo L. [Primitive carcinoid tumor of the middle ear: a case report and review of literature]. Acta Otorhinolaryngol Ital. 1999;19(2):91–6.Google Scholar
  15. 15.
    Hosoda S, Tateno H, Inoue HK, Isojima G, Kondo S, Konishi T. Carcinoid tumor of the middle ear containing serotonin and multiple peptide hormones. A case report and review of the pathology literature. Acta Pathol Jpn. 1992;42(8):614–20.PubMedGoogle Scholar
  16. 16.
    Phelps PD, Lloyd GA. Magnetic resonance with gadolinium DTPA for the investigation of temporal bone tumours. Clin Otolaryngol Allied Sci. 1989;14(3):251–62.PubMedCrossRefGoogle Scholar
  17. 17.
    Nikanne E, Kantola O, Parviainen T. Carcinoid tumor of middle ear. Acta Otolaryngol. 2002;119(11):1081–4.Google Scholar
  18. 18.
    Pellini R, Ruggieri M, Pichi B, Covello R, Danesi G, Spriano G. A case of cervical metastases from temporal bone carcinoid. Head Neck. 2005;27(7):644–7.PubMedCrossRefGoogle Scholar
  19. 19.
    Bold EL, Wanamaker JR, Hughes GB, Rhee CK, Sebek BA, Kinney SE. Adenomatous lesions of the temporal bone immunohistochemical analysis and theories of histogenesis. Am J Otol. 1995;16(2):146–52.PubMedGoogle Scholar
  20. 20.
    Batsakis JG. El-Naggar AK. Papillary neoplasms (Heffner’s tumors) of the endolymphatic sac. Ann Otol Rhinol Laryngol. 1993;102(8 Pt 1):648–51.PubMedCrossRefGoogle Scholar
  21. 21.
    Latif M, Madders D, Barton R, Shaw P. Carcinoid tumour of the middle ear associated with systemic symptoms. J Laryngol Otol. 1987;101(05):480–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Murphy GF, Pilch ZB, Dickersin GR, Goodman ML, Nadol JB. Carcinoid tumor of the middle ear. Am J Clin Pathol. 1980;73(6):816–23.PubMedCrossRefGoogle Scholar
  23. 23.
    Marchioni D, Alicandri-Ciufelli M, Gioacchini FM, Bonali M, Presutti L. Transcanal endoscopic treatment of benign middle ear neoplasms. Eur Arch Otorhinolaryngol. 2013;270(12):2997–3004.PubMedCrossRefGoogle Scholar
  24. 24.
    Morita M, Mori N, Takashima H, Miki H, Sakai SI. Primary poorly differentiated adenocarcinoma of the middle ear. Auris Nasus Larynx. 1994;21(1):59–63.PubMedCrossRefGoogle Scholar
  25. 25.
    Carroll WR, Niparko JK, Zappia JJ, McClatchey KD. Primary adenocarcinoma of the temporal bone. A case with 40-year follow-up. Arch Otolaryngol Head Neck Surg. 1991;117(4):439–41.PubMedCrossRefGoogle Scholar
  26. 26.
    Glasscock ME 3rd, McKennan KX, Levine SC, Jackson CG. Primary adenocarcinoma of the middle ear and temporal bone. Arch Otolaryngol Head Neck Surg. 1987;113(8):822–4.PubMedCrossRefGoogle Scholar
  27. 27.
    Devaney KO, Boschman CR, Willard SC, Ferlito A, Rinaldo A. Tumours of the external ear and temporal bone. Lancet Oncol. 2005;6(6):411–20.PubMedCrossRefGoogle Scholar
  28. 28.
    Thompson LD, Nelson BL, Barnes EL. Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature. Am J Surg Pathol. 2004;28(3):308–18.PubMedCrossRefGoogle Scholar
  29. 29.
    Merrick Y. Metastatic colon adenocarcinoma of the middle ear. Arch Otorhinolaryngol. 1983;238(2):103–5.PubMedCrossRefGoogle Scholar
  30. 30.
    Paulus W, Romstock J, Weidenbecher M, Huk WJ, Fahlbusch R. Middle ear adenocarcinoma with intracranial extension. Case report. J Neurosurg. 1999;90(3):555–8.PubMedCrossRefGoogle Scholar
  31. 31.
    McDonald M, Brophy BP, Raymond W. Intracranial invasion from a primary adenocarcinoma arising in the middle and external ear. Aust N Z J Surg. 1995;65(6):454–6.PubMedCrossRefGoogle Scholar
  32. 32.
    Mansour P, George MK, Pahor AL. Ceruminous gland tumours: a reappraisal. J Laryngol Otol. 1992;106(8):727–32.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    van der Putten L, Bloemena E, Merkus P, Hensen EF. Schneiderian papilloma of the temporal bone. BMJ Case Rep. 2013;2013Google Scholar
  34. 34.
    Shen J, Baik F, Mafee MF, Peterson M, Nguyen QT. Inverting papilloma of the temporal bone: case report and meta-analysis of risk factors. Otol Neurotol. 2011;32(7):1124–33.PubMedCrossRefGoogle Scholar
  35. 35.
    Stone DM, Berktold RE, Ranganathan C, Wiet RJ. Inverted papilloma of the middle ear and mastoid. Otolaryngol Head Neck Surg. 1987;97(4):416–8.PubMedCrossRefGoogle Scholar
  36. 36.
    Jones ME, Wackym PA, Said-Al Naief N, Brandwein M, Shaari CM, Som PM, et al. Clinical and molecular pathology of aggressive schneiderian papilloma involving the temporal bone. Head Neck. 1998;20(1):83–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Chhetri D, Gajjar N, Bhuta S, Andrews J. Pathology forum. Quiz case 2. Schneiderian-type papilloma of the middle ear. Arch Otolaryngol Head Neck Surg. 2001;127:79,80–2.Google Scholar
  38. 38.
    Liu ZW, Walden A, Lee CA. Sinonasal inverted papilloma involving the temporal bone via the eustachian tube: case report. J Laryngol Otol. 2013;127(3):318–20.PubMedCrossRefGoogle Scholar
  39. 39.
    Altug T, Sunar O, Bilgin H. [Inverted papilloma. Apropos of a multicentric case]. Rev Laryngol Otol Rhinol (Bord). 1989;110(3):299–301.Google Scholar
  40. 40.
    Miller PJ, Jacobs J, Roland JT, Cooper J, Mizrachi HH. Intracranial inverting papilloma. Head Neck. 1996;18(5):450–4.PubMedCrossRefGoogle Scholar
  41. 41.
    Pou AM, Vrabec JT. Inverting papilloma of the temporal bone. Laryngoscope. 2002;112(1):140–2.PubMedCrossRefGoogle Scholar
  42. 42.
    Carlson ML, Sweeney AD, Modest MC, Van Gompel JJ, Haynes DS, Neff BA. Inverting papilloma of the temporal bone: report of four new cases and systematic review of the literature. Laryngoscope. 2015;125(11):2576–83.PubMedCrossRefGoogle Scholar
  43. 43.
    Uchida M, Fujita T, Okamoto K, Ueda M, Ushijima C, Dejima K. [A case of Schneiderian middle-ear and sinonasal papilloma with intracranial complications]. Nihon Jibiinkoka Gakkai Kaiho. 2011;114(9):768–73.PubMedCrossRefGoogle Scholar
  44. 44.
    Uchida M, Fujita T, Okamoto K, Ueda M, Ushijima C, Dejima K. A case of Schneiderian middle-ear and sinonasal papilloma with intracranial complications. Nihon Jibiinkoka Gakkai Kaiho. 2011;114(9):768–73.PubMedCrossRefGoogle Scholar
  45. 45.
    Dingle I, Stachiw N, Bartlett A, Lambert P. Bilateral inverted papilloma of the middle ear with intracranial involvement and malignant transformation: first reported case. Laryngoscope. 2012;122(7):1615–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Marioni G, Altavilla G, Busatto G, Blandamura S, De Filippis C, Staffieri A. Detection of human papillomavirus in temporal bone inverted papilloma by polymerase chain reaction. Acta Otolaryngol. 2003;123(3):367–71.PubMedCrossRefGoogle Scholar
  47. 47.
    Blandamura S, Marioni G, de Filippis C, Giacomelli L, Segato P, Staffieri A. Temporal bone and sinonasal inverted papilloma: the same pathological entity? Arch Otolaryngol Head Neck Surg. 2003;129(5):553–6.PubMedCrossRefGoogle Scholar
  48. 48.
    Calderon-Garciduenas L, Delgado R, Calderon-Garciduenas A, Meneses A, Ruiz LM, De La Garza J, et al. Malignant neoplasms of the nasal cavity and paranasal sinuses: a series of 256 patients in Mexico City and Monterrey. Is air pollution the missing link? Otolaryngol Head Neck Surg. 2000;122(4):499–508.PubMedGoogle Scholar
  49. 49.
    Sham CL, Lee DL, Cv H, Tong MC. A case-control study of the risk factors associated with sinonasal inverted papilloma. Am J Rhinol Allergy. 2010;24(1):e37–40.PubMedCrossRefGoogle Scholar
  50. 50.
    Zhou H, Chen Z, Li H, Xing G. Primary temporal inverted papilloma with premalignant change. J Laryngol Otol. 2011;125(2):206–9.PubMedCrossRefGoogle Scholar
  51. 51.
    Wassef S, Battra P, Barnett S. Skull base inverted papilloma: a comprehensive review. ISRN Surg. 2012;2012:175903.PubMedPubMedCentralCrossRefGoogle Scholar
  52. 52.
    Acevedo-Henao CM, Talagas M, Marianowski R, Pradier O. Recurrent inverted papilloma with intracranial and temporal fossa involvement: a case report and review of the literature. Cancer Radiother. 2010;14(3):202–5.PubMedCrossRefGoogle Scholar
  53. 53.
    Wenig BM. Lymphoepithelial-like carcinomas of the head and neck. Semin Diagn Pathol. 2015;32(1):74–86.PubMedCrossRefGoogle Scholar
  54. 54.
    Tysome JR, Harcourt J, Patel MC, Sandison A, Michaels L. Aggressive papillary tumor of the middle ear: a true entity or an endolymphatic sac neoplasm? Ear Nose Throat J. 2008;87(7):378–81.PubMedGoogle Scholar
  55. 55.
    Muller M, Zammit-Maempel I, Hill J, Wilkins B. An unusual middle-ear mass. J Laryngol Otol. 2010;124(1):108–10.PubMedCrossRefGoogle Scholar
  56. 56.
    Schick B, Kronsbein H, Kahle G, Prescher A, Draf W. Papillary tumor of the temporal bone. Skull Base. 2001;11(1):25–33.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Levin RJ, Feghali JG, Morganstern N, Llena J, Bradley MK. Aggressive papillary tumors of the temporal bone: an immunohistochemical analysis in tissue culture. Laryngoscope. 1996;106(2 Pt 1):144–7.PubMedCrossRefGoogle Scholar
  58. 58.
    Kawabata S, Hollander MC, Munasinghe JP, Brinster LR, Mercado-Matos JR, Li J, et al. Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone. Oncotarget. 2015;6(13):11357–68.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Head and Neck SurgeryThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

Personalised recommendations