What About Stem Cells?

  • Andreas Bikfalvi


Takayuki Asahara and the late Jeffrey Isner, then director of a laboratory at the Dana Farber Institute in Boston (he died of myocardial infarction in 2001), had isolated circulating endothelial precursor cells using immunoabsorption with an antibody Anti-AC113 [279]. The AC113 antigen is expressed on a number of stem cells. When cultured, these cells acquire endothelial cell characteristics. Thus, peripheral blood contains progenitor cells capable of differentiating into endothelial cells.


  1. 279.
    Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T (1999) Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5(4):434–438. https://doi.org/10.1038/7434CrossRefPubMedGoogle Scholar
  2. 280.
    Seandel M, Butler J, Lyden D, Rafii S (2008) A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization. Cancer Cell 13(3):181–183. https://doi.org/10.1016/j.ccr.2008.02.016CrossRefPubMedPubMedCentralGoogle Scholar
  3. 281.
    Bompais H, Chagraoui J, Canron X, Crisan M, Liu XH, Anjo A, Tolla-Le Port C, Leboeuf M, Charbord P, Bikfalvi A, Uzan G (2004) Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells. Blood 103(7):2577–2584. https://doi.org/10.1182/blood-2003-08-2770CrossRefPubMedGoogle Scholar
  4. 282.
    Leroyer AS, Anfosso F, Lacroix R, Sabatier F, Simoncini S, Njock SM, Jourde N, Brunet P, Camoin-Jau L, Sampol J, Dignat-George F (2010) Endothelial-derived microparticles: biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis. Thromb Haemost 104(3):456–463. https://doi.org/10.1160/TH10-02-0111CrossRefPubMedGoogle Scholar
  5. 283.
    Gao D, Mittal V (2009) The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends Mol Med 15(8):333–343. https://doi.org/10.1016/j.molmed.2009.06.006CrossRefPubMedGoogle Scholar
  6. 284.
    Purhonen S, Palm J, Rossi D, Kaskenpaa N, Rajantie I, Yla-Herttuala S, Alitalo K, Weissman IL, Salven P (2008) Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A 105(18):6620–6625. https://doi.org/10.1073/pnas.0710516105CrossRefPubMedPubMedCentralGoogle Scholar
  7. 285.
    Kerbel RS, Benezra R, Lyden DC, Hattori K, Heissig B, Nolan DJ, Mittal V, Shaked Y, Dias S, Bertolini F, Rafii S (2008) Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas. Proc Natl Acad Sci U S A 105(34):E54; author reply E55. doi:https://doi.org/10.1073/pnas.0804876105CrossRefGoogle Scholar
  8. 286.
    Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C (2005) Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11(3):261–262. https://doi.org/10.1038/nm1200CrossRefPubMedGoogle Scholar
  9. 287.
    Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, Cenci T, Maira G, Parati EA, Stassi G, Larocca LM, De Maria R (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468(7325):824–828. https://doi.org/10.1038/nature09557CrossRefPubMedGoogle Scholar
  10. 288.
    Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, Geber A, Fligelman B, Leversha M, Brennan C, Tabar V (2010) Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468(7325):829–833. https://doi.org/10.1038/nature09624CrossRefPubMedGoogle Scholar
  11. 289.
    Golebiewska A, Bougnaud S, Stieber D, Brons NH, Vallar L, Hertel F, Klink B, Schrock E, Bjerkvig R, Niclou SP (2013) Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells. Brain 136(Pt 5):1462–1475. https://doi.org/10.1093/brain/awt025CrossRefPubMedPubMedCentralGoogle Scholar
  12. 290.
    Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN, Bao S (2013) Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell 153(1):139–152. https://doi.org/10.1016/j.cell.2013.02.021CrossRefPubMedPubMedCentralGoogle Scholar
  13. 291.
    Williamson SC, Metcalf RL, Trapani F, Mohan S, Antonello J, Abbott B, Leong HS, Chester CP, Simms N, Polanski R, Nonaka D, Priest L, Fusi A, Carlsson F, Carlsson A, Hendrix MJ, Seftor RE, Seftor EA, Rothwell DG, Hughes A, Hicks J, Miller C, Kuhn P, Brady G, Simpson KL, Blackhall FH, Dive C (2016) Vasculogenic mimicry in small cell lung cancer. Nat Commun 7:13322. https://doi.org/10.1038/ncomms13322CrossRefPubMedPubMedCentralGoogle Scholar
  14. 292.
    Sanchez-Duffhues G, Orlova V, Ten Dijke P (2016) In Brief: Endothelial-to-mesenchymal transition. J Pathol 238(3):378–380. https://doi.org/10.1002/path.4653CrossRefPubMedGoogle Scholar
  15. 293.
    Arderiu G, Espinosa S, Pena E, Crespo J, Aledo R, Bogdanov VY, Badimon L (2017) Tissue factor variants induce monocyte transformation and transdifferentiation into endothelial cell-like cells. J Thromb Haemost 15(8):1689–1703. https://doi.org/10.1111/jth.13751CrossRefPubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Andreas Bikfalvi
    • 1
  1. 1.Angiogenesis and Tumor Microenvironment LaboratoryUniversity of Bordeaux and National Institute of Health and Medical ResearchPessacFrance

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