Adenomatous Polyposis Syndromes: MUTYH-Associated Polyposis

  • Maartje Nielsen
  • Stephan Aretz


MUTYH-associated polyposis was first described in 2002. It is inherited recessively, and patients usually develop between tens and hundreds of adenomas throughout life. The risk of developing colon cancer when surveillance is not started in time is very high. In this chapter the clinical aspects, cancer risk, mutation spectrum, risk for heterozygotes and tumour characteristics will be described.


MUTYH- associated polyposis (MAP) Polyposis MUTYH 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Clinical GeneticsLeiden University Medical CentreLeidenThe Netherlands
  2. 2.Institute of Human Genetics, Center for Hereditary Tumor Syndromes, University of BonnBonnGermany

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