Skip to main content
SpringerLink
Log in

Composition of Aroma Compounds in Salvia spp. from Bulgaria and Their Potential Practical Applications

  • Chapter
  • First Online:
Salvia Biotechnology

Abstract

The aim of present chapter is to gather the information about chemical composition, biological activities and possible applications of essential oils from seven different species of Genus Salvia growing in Bulgaria (S. officinalis L., S. sclarea L., S. tomentosa Mill, S. scabiosifolia Lam., S. ringens Sibth. et Sm., S. amplexicaulis Lam. and S. aethiopis L.). The chapter is focused on the variations in chemical composition of the essential oil caused by different climate and agro-industrial factors. Different forms of bioactivities of essential oils from Salvia spp. growing in Bulgaria and their possible applications are also discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bown D (1995) Encyclopedia of herbs and their uses. Dorling Kindersley, London

    Google Scholar 

  2. Chevallier A (2009) The Encyclopedia of medicinal plants. Dorling Kindersley, London

    Google Scholar 

  3. Kintzios S (2000) Sage—the genus Salvia. Harwood Amsterdam, Netherland

    Google Scholar 

  4. Abu-Darwish M, Cabral C, Ferreira I et al (2013) Essential oil of common sage (Salvia officinalis L.) from Jordan: assessment of safety in mammalian cells and its antifungal and Anti-inflammatory potential. Bio Med Res Int, Article ID 538940:1–9

    Google Scholar 

  5. Dobetsberger C, Buchbauer G (2011) Actions of essential oils on the central nervous system: an updated review. Flavour Fragr J 26(5):300–316

    Article  CAS  Google Scholar 

  6. Kamatou G, Vilijoen A, Gono-Bwalya AB (2005) The in vitro pharmacological activities and a chemical investigation of three South African species. J Ethnopharmacol 102(3):382–390

    Article  CAS  PubMed  Google Scholar 

  7. Markova M (1989) Genus Salvia in Flora Bulgaricae. Sofia Acad Sci Bulg 9:442

    Google Scholar 

  8. Dikova B (2011) Tomato spotted wilt virus on some medicinal and essential oil-bearing plants in Bulgaria. Bulg J Agric Sci 17(3):306–313

    Google Scholar 

  9. Georgiev E, Stoyanova A (2006) A guide for the specialist in aromatic industry. Plovdiv, Bulgaria

    Google Scholar 

  10. Petrova A, Vladimirov V (2009) Red list of Bulgarian vascular plants. Phytologia Balcanica 15:63–94

    Google Scholar 

  11. Tashev A, Tsavkov E (2008) medicinal plants of the Bulgarian dendroflora. Phytologia Balcanica 14:269–278

    Google Scholar 

  12. Fägäras M, Anastasiu P, Gavril N (2010) Rare and threatened plants in the Black Sea coastal area between Cape Midia (Romania) and Cape Kaliakra (Bulgaria). Botanica Serb 34:37–43

    Google Scholar 

  13. Badiee P, Nasirzadeh A, Motaffal M (2012) Comparison of Salvia officinalis L. essential oil and antifungal agents against candida species. J Pharm Technol Drug Res 1(7):1–6

    Google Scholar 

  14. Bașer H, Kirimer N (2006) Essential oils of Lamiaceae plants of Turkey (Conference Paper). Acta Hort 723:163–171

    Google Scholar 

  15. Mirijalili M, Salehi P, Sonboli A, Vala M (2006) Essential oil variation of Salvia officinalis aerial parts during its phenological cycle. Chem Nat Compd 42(1):19–23

    Article  Google Scholar 

  16. Raal A, Orav A, Arak E (2007) Composition of the essential oil of Salvia officinalis L., from varios European countres. Nat Prod Res 21(5):406–411

    Article  CAS  PubMed  Google Scholar 

  17. Abu-Darwish M, Cabral C, Ferreira I, Gonçalves M, Cavaleiro C, Cruz M, Al-Bdour T, Salgueiro I (2013) Essential oil of Common Sage (Salvia officinalis L.) from Jordan: assessment of safety in mammalian cells and its antifungal and Anti-inflammatory potential. Bio Med Res Int, Article ID 538940:1–9

    Google Scholar 

  18. Fu Z, Wang H, Hu X, Sun Z, Han C (2013) The Pharmacological properties of Salvia essential Oil. J Appl Pharm Sci 3(07):122–127

    Google Scholar 

  19. Loizzo R, Tundis R, Menichini F, Saab M, Statti A, Menichini F (2007) Cytotoxic activity of essential oils from Labiatae and Lauraceae families against in vitro human tumor models. Anticancer Res 27:3293–3300

    CAS  PubMed  Google Scholar 

  20. Mahboubi E, Ahmadi A (2013) Evalution of Salvia officinalis antifungal properties on the growth and morphogenesis of Alternaria alternata under in-vitro conditions. Tech J Eng Appl Sci 3(17):2062–2069

    Google Scholar 

  21. Djeddi S, Bouchenak N, Settar I, Halli L (2012) Screening of chemical composition and antimicrobial potential of Algerian sage essential oil. Glob J Med Plant Res 1(1):46–49

    Google Scholar 

  22. Lakhal H, Ghorab H, Chibani S, Kabauche A, Semra Z, Smati Z, Smati F, Abuhamdah S, Kabouche Z (2013) Chemical composition and biological activities of the essential oil of Salvia officinalis from Batna (Algeria). Scholars Res Libr 5(3):310–314

    CAS  Google Scholar 

  23. Orhan I, Özçelik B, Kartal M, Kan Y (2012) Antimicrobial and antiviral effects of essential oils from selected Umbeliferae and Labiatae plants and individual essential oil components. Turk J Biol 36:239–246

    CAS  Google Scholar 

  24. Pinto E, Salguero L, Cavaleiro C, Palmeira A, Gonzalves M (2007) In vitro susceptibility of some species of yeasts and filamentous fungi to essential oils of Salvia officinalis. Ind Crops Prod 26(2):135–141

    Article  CAS  Google Scholar 

  25. Soković M, Clamoćlija J, Ćirić A, Kataranovski D, Marin PD, Vukojević J, Brkić D (2012) Antifungal activity of the essential oils and components in vitro and in vivo on experimentally induced dermatomycoses at rats. Dig J Nanomater Biostruct 7(3):959–966

    Google Scholar 

  26. Miladinović D, Mihajilov-Krstev S, Nikolić M, Miladinović D, Cvetković C (2012) Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods. Anal Bioanal Chem 403(4):1007–1018

    Article  PubMed  Google Scholar 

  27. Gildemeister E, Hoffman F (1961) Die Ätherischen Öle. VII. Akademie Verlag, Berlin

    Google Scholar 

  28. Balinova-Tzvetkova A, Tsoneva D, Tsankova P et al (1987) Essential oil from garden sage. In: Scientific conference “80 years scientific work with essential oil bearing plants in Bulgaria”, 21–22 Oct 1987

    Google Scholar 

  29. Tsankova E, Konaktchiev A, Genova E (1994) Constituents of essential oils from three Salvia species. J Essent Oil Res 6:375–378

    Article  CAS  Google Scholar 

  30. Zheljazkov V, Craker L, Xing B et al (2008) Aromatic plant production on metal contaminated soils. Sci Total Environ 395:51–62

    Article  CAS  PubMed  Google Scholar 

  31. Stancheva I, Geneva M, Hriztozkova M et al (2009) Essential oil variation of Salvia officinalis (L.), grown on heavy metals polluted soil. Biotechnol Equip 23:373–376

    Article  Google Scholar 

  32. Zheljazkov V, Astatide T, Shiwakoti S et al (2014) Essential oil yield and composition of garden sage as a function of different steam distillation times. HoartScience 49(6):785–790

    Google Scholar 

  33. Hristova Y (2015) Inhibitory activity of essential oils from Bulgarian essential oil bearing plants against medically important fungi from genus Candida. Ph.D. thesis, “Paisii Hilendarski” University of Plovdiv, Bulgaria

    Google Scholar 

  34. Pozzatti P, Loreto É, Nunes M et al (2010) Activities of essential oils in the inhibition of Candida albicans and Candida dubliniensis germ tube formation. J Mycol Méd 20:185–189

    Article  Google Scholar 

  35. Tullio V, Nostro A, Mandras N et al (2006) Antifungal activity of essential oils against filamentous fungi determined by broth microdilution and vapour contact methods. J Appl Microbiol 102:1544–1550

    Article  Google Scholar 

  36. ISO 9909:1997 (1997) Oil of Dalmatian sage (Salvia officinalis L.). International Standard Organization

    Google Scholar 

  37. Atanasova T, Nenov N, Dimitrova-Djulgerova I et al (2012) Chemical composition of aromatic products, 1. Sage (Salvia officinalis L.). Sci Works Univ Food Technol 61:275–278

    Google Scholar 

  38. Balinova A, Diakov G (1974) On improved apparatus for microdistillation of rose flowers. Plant Sci:79–85

    Google Scholar 

  39. Tabassum N, Vidiasagar G (2013) Antifungal investigations on plant essential oils: a review. Int J Pharm Pharm Sci 5(2):19–28

    Google Scholar 

  40. Alizadeh A, Shaabani M (2012) Essential oil composition, phenolic content, antioxidant and antimicrobial activity in Salvia officinalis L. cultivated in Iran. Adv Environ Biol 6(1):221–226

    Google Scholar 

  41. Hosseinzadeh H, Sadeghnia HR, Imenshahidi M, Fazly B (2009) Review of the pharmacological and toxicological effects of Salvia leriifolia. Iran J Basic Med Sci 12:1–8

    Google Scholar 

  42. Naeni A, Khosravi A, Chitsaz M, Shokri H, Kamlnejad M (2009) Anti-Candida albicans activity of some Iranian plants used in traditional medicine. J Mycol Méd 19:168–172

    Article  Google Scholar 

  43. Zuzarte M, Gonçalves M, Canhoto J, Salgueiro L (2011) Antidermatophytic activity of essential oils, In: Méndez-Vilas A (ed) Science against microbial pathogens: communicating current research and technological advances. FORMATEX, Badajoz, pp 1167–1178

    Google Scholar 

  44. Nestorova V, Georgiev E, Balinova A (1989) About the antimicrobial effect of some food spices. 4. Essential oils obtained from spearmint, rosemary, sage, milfoil, monarda and marjoram. In: VIIth congress on Microbiology. Varna, Bulgaria, 27–29 October

    Google Scholar 

  45. Gurgulova K, Nenchev P, Zhelyazkova I et al (2006) Study on the antibacterial and antimycotic activity of some ethereal oils to strains of microorganisms causing diseases in bees and brood. Ecol Fut - J Agric Sci For Sci 5:32–36

    Google Scholar 

  46. Clinical Laboratory Standard Institute (2009) Reference method for antifungal disk diffusion susceptibility testing of yeasts; Approved guideline-second edition. M44-A2, vol 29, no 7. Wayene, USA

    Google Scholar 

  47. Clinical Laboratory Standard Institute (2008) Reference method for Broth dilution antifungal susceptibility testing of yeasts. Approved standard-third edition. M27-A 28 vol 28, no 14. Wayene, USA

    Google Scholar 

  48. el Hayouni A, Chraief I, Abedrabba M et al (2008) Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat. Int J Food Microbiol 125:242–251

    Article  CAS  Google Scholar 

  49. Amalieva K (2011) Investigation on the influence of essential oils and their mixture in aroma preparations. Ph.D. Thesis, University of Food Technologies Plovdiv, Bulgaria

    Google Scholar 

  50. Sharopov F, Setzer N (2012) The essential oil of Salvia sclarea L. from Tajikistan. Rec Nat Prod 6(1):75–79

    CAS  Google Scholar 

  51. Džamić A, Soković M, Ristić M, Grujić-Jovanović S, Vukojević J, Marina P (2008) Chemical composition and antifungal activity of Salvia sclarea (Lamiaceae) essential oil. Arch. Biol. Sci. Belgrade 60(2):233–237

    Article  Google Scholar 

  52. Fratenale D, Glampert L, Bucchini A, Ricci D, Epifano F, Genovese S, Curini M (2005) Composition and antifungal activity of essential oil of Salvia sclarea from Italia. Chem Nat Compd 41(5):604–606

    Article  Google Scholar 

  53. Jirovets L, Wlcek K, Buchbauer G, Gochev V, Girova T, Stoyanova A, Schmidt E (2007) Antifungal activities of essential oils of Salvia lavandulifolia, Salvia officinalis and Salvia sclarea against various Pathogenic Candida species. J Essent Oil Bear Plants 10(5):430–439

    Article  Google Scholar 

  54. Pitarokili D, Couladis M, Petsikos-Panayotarou N, Tzakou O (2002) Composition and antifungal activity on soil-borne pathogens of the essential oil of Salvia sclarea from Greece. J Agric Food Chem 6(50):6688–6691

    Article  Google Scholar 

  55. Taârit MB, Msaada K, Hosni K, Marzouk B (2014) GC analyses of salvia seeds as valuable essential oil source. Adv Chem, Article ID 838162, 6

    Google Scholar 

  56. Lorenzo D, Paz D, Davies P (2004) Characterization and enantiomeric distribution of some terpenes in the essential oil of a Uruguayan biotype of Salvia sclarea L. Flavour Fragr J 19(4):303–307

    Article  CAS  Google Scholar 

  57. Ilieva S, Dimitrova E, Zolotovitch G (1955) The production of essential oil of Salvia sclarea L. in Bulgaria (first announcement). C R l’Acad Bulg Sci 8(1): 49–52

    Google Scholar 

  58. Dimitrova E, Ilieva S, Zolotovitch G (1955) La production d’hule de Salvia sclarea en Bulgarie. C R l’Acad Bulg Sci 8(3):13–16

    CAS  Google Scholar 

  59. Ilieva S, Nikolov N, Ivanov I et al (1978) New modifications of Salvia sclarea L. with a high essential oil content. In: Third National Conference “Problems of cosmetics and perfumery”. Varna, Bulgaria, 15–17 October

    Google Scholar 

  60. Ilieva S (1979) New Salvia sclarea cultivars developed by hybridization. Herba Hungarica 18(3):197–203

    CAS  Google Scholar 

  61. Ilieva S, Grigorova P, Tsutsulova A (1985) Cultivar Salvia sclarea with higher yield and quality of essential oil. In: Five National Conference of aromatic “Problems of cosmetics and perfumery”. Varna, Bulgaria, 17–19 October

    Google Scholar 

  62. Kovatcheva N, Zheljazkov V (1996) Essential oil content and components of Salvia officinalis L. from Bulgaria. In: 27th International Symposium on Essential Oils. Vienna

    Google Scholar 

  63. Lawrence B (2001) Progress in essential oil. Sage oil Perfum Flavour 26(3):66–79

    CAS  Google Scholar 

  64. Hristova Y, Gochev V, Wanner J et al (2013) Chemical composition and antifungal activity of essential oil of Salvia sclarea L. from Bulgaria against clinical isolates of Candida species. J BioSci Biotechnol 2(1):39–44

    Google Scholar 

  65. Yousefzadia M, Sonbolib A, Karimic F et al (2007) Antimicrobial activity of some Salvia species essential oils from Iran. Z Naturforsch 62:514–518

    Google Scholar 

  66. Gurgulova K, Nenchev P, Zhelyazkova I et al (2006) Study on biological activity of some essential oils to microorganisms Bacillus cereus and Bacillus subtilis. J Anim Sci 43:42–45

    Google Scholar 

  67. Rusenova N, Parvanov P (2009) Antimicrobial activities of twelve essential oils against microorganisms of veterinary importance. Trakia J Sci 7(1):37–43

    Google Scholar 

  68. Roussenova N (2011) Antibacterial activity of essential oils against the etiological agent of American foulbrood disease (Paenibacillus larvae). Bul J Veter Med 14(1):17–24

    Google Scholar 

  69. Georgiev V, Marchev A, Haas C et al (2011) Production of oleanolic and ursolic acids by callus cultures of Salvia tomentosa Mill. Biotechnol Biotechnol Equip 25(4):34–38

    Article  Google Scholar 

  70. Marchev A, Ivanov I, Denev P et al (2015) Acetylcholinesterase inhibitory, antioxidant, and antimicrobial activities of Salvia tomentosa Mill. essential oil. J BioSci Biotechnol 4(2):219–229

    Google Scholar 

  71. Marchev A, Georgiev V, Nikolova M et al (2012) Chemical composition of essential oil from Salvia scabiosifolia from Bulgaria. J Essent Oil Bear Pl 15(6):908–914

    Article  Google Scholar 

  72. Nikolova M, Janicsak Genova E et al (2006) Comparative analysis of extremal flavonoids of Bulgarian and Hungarian samples of Salva species. Acta Bot Hung 48:361–367

    Article  Google Scholar 

  73. Georgiev V, Marchev A, Nikolova M et al (2013) Chemical composition of essential oil from leaves and flowers of Salvia ringens Sibth. et Sm. growing wild in Bulgaria. J Essent Oil Bear Pl 16(5):624–629

    Google Scholar 

  74. Bozov P, Atanasova T, Merdzhanov P et al (2016) Chemical composition of the essential oils of Salvia amplexicaulis Lam. and Ajuga laxmanii Benth. from Bulgaria. J Food Packag Sci Technol Technol 5:14–17

    Google Scholar 

  75. Petrovic S, Pavlovic M, Tzakou O et al (2009) Composition and antimicrobial activity of Salvia amplexicaulis Lam. essential oil. J Essent Oil Res 21:563–566

    Article  CAS  Google Scholar 

  76. Velickovic D, Ristic M, Milosavlievic N et al (2012) Chemical composition of the essential oils of Salvia austriaca Jacq. and Salvia amplexicaulis Lam. from Serbia. Agro Food Ind Tech 5:56–58

    Google Scholar 

  77. Damyanova S, Stoyanova A, Bozov P et al (2016) Chemical composition of essential oil from Salvia aethiopis L. from Bulgaria. Ukr Food J 5:497–504

    Article  Google Scholar 

  78. Chalchat J-C, Gorunovic M, Petrovic S et al (1999) Chemical composition of two wild species of the genus Salvia L. from Yugoslavia: Salvia aethiopis and Salvia verticillata. J Essent Oil Res 13(6):416–418

    Google Scholar 

  79. Velickovic D, Ristic M, Velickovic A (2003) Chemical composition of the essential oils obtained from the flower, leaf and stem of Salvia aethiopis L. and Salvia glutinosa L. originating from the southeast region of Serbia. J Essent Oil Res 15 (5):346–349

    Google Scholar 

  80. Morteza-Semnani K, Goodarzi A, Azadcakht M (2005) The essential oil of Salvia aethiopis L. J Essent Oil Res 17(3):274–275

    Article  CAS  Google Scholar 

  81. Tajbakhsh M, Rineh A, Khalilzadeh M et al (2007) Chemical constituents of the essential oils from leaves, flowers, stem and aerial parts of Salvia aethiopis L. from Iran. J Essent Oil Res 19(6):569–571

    Google Scholar 

  82. Torres E, Velasco-Negueruela A, Perez-Alonso M et al (1997) Volatile constituents of two Salvia species grown wild in Spain. J Essent Oil Res 9(1):27–33

    Article  CAS  Google Scholar 

  83. Gϋllϋce M, Ozer H, Bariş O et al (2006) Chemical composition of the essential oil of Salvia aethiopis L. Turk J Biol 30:231–233

    Google Scholar 

Download references

Acknowledgements

Experimental work and studies of the authors was financially supported by Project NI15/FK012 by “P. Hilendarski” University of Plovdiv.

Author information

Authors and Affiliations

  1. Department of Biochemistry and Microbiology, “Paisii Hilendarski” University of Plovdiv, Plovdiv, Bulgaria

    Velizar Gochev & Tanya Girova

  2. Food Research and Development Institute at Agricultutal Academy, Plovdiv, Bulgaria

    Yana Hristova

  3. Department of Tobacco, Sugar, Vegetable and Essential Oils, University of Food Technologies, Plovdiv, Bulgaria

    Albena Stoyanova

Authors
  1. Velizar Gochev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yana Hristova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tanya Girova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Albena Stoyanova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Velizar Gochev .

Editor information

Editors and Affiliations

  1. Laboratory of Applied Biotechnology, The Stephan Angeloff Institute of Microbiology-BAS, Plovdiv, Bulgaria

    Vasil Georgiev

  2. Department of Analytical Chemistry, University of Food Technologies, Plovdiv, Bulgaria

    Atanas Pavlov

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gochev, V., Hristova, Y., Girova, T., Stoyanova, A. (2017). Composition of Aroma Compounds in Salvia spp. from Bulgaria and Their Potential Practical Applications. In: Georgiev, V., Pavlov, A. (eds) Salvia Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-319-73900-7_3

Download citation

Publish with us

Policies and ethics

Search

Navigation