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Omega-3: An Intelligent Decision for Brain Nutrition

  • Socorro Herrera Meza
  • Grecia Herrera Meza
Chapter
Part of the The Anthropocene: Politik—Economics—Society—Science book series (APESS, volume 23)

Abstract

Chronic degenerative diseases put the health of the general population at risk. However, the information given to the population to prevent or decrease the incidence of illness does not always reach its intended audience or is inaccurate, as in the case of information regarding polyunsaturated fatty acids such as ω-3, found in aquatic animals and some seeds. It has been observed that supplementation with ω-3 prevents cardiovascular diseases and strokes; reduces triglycerides, blood pressure, formation of thrombi and arrhythmia; alleviates cutaneous lesions resulting from psoriasis, rheumatoid arthritis, nephropathy and asthma; and decreases the metastasis of prostate, breast and colon cancer. Decrease in ω-3 levels, on the other hand, is associated with dementia, migraines, post-partum depression bipolarity, symptoms of depression and aggression, and neurological disorders relating to memory, attention and information processing. If the information on ω-3 were widely available, people would be able to choose what they eat and create a culture of prevention, thus decreasing the risk factors.

Keywords

ω-3 Supplementation Cardiovascular problems Neurological disorders Prevention 

References

  1. Alwan, A. (2011). Global status report on noncommunicable diseases 2010. World Health Organization.Google Scholar
  2. Arab-Tehrany, E., Jacquot, M., Gaiani, C., Imran, M., Desobry, S., Linder, M. (2012). Beneficial effects and oxidative stability of omega-3 long-chain polyunsaturated fatty acids. Trends in Food Science & Technology, 25, 24–33(2012).  https://doi.org/10.1016/j.tifs.2011.12.002.
  3. Badui, D.S. (2006). Lípidos. En Química de los Alimentos (4a ed). México: Pearson Education.Google Scholar
  4. Ballesteros-Vásquez, M.N., Valenzuela-Calvillo, L.S., Artalejo-Ochoa E., Robles-Sardin, A.E. (2012). Ácidos grasos trans: un análisis del efecto de su consumo en la salud humana, regulación del contenido en alimentos y alternativas para disminuirlos. Nutrición Hospitalaria. Scielo, 27(1), 54–64 (2012).Google Scholar
  5. Bazan, N.G. (2005). Lipid signaling in neural plasticity, brain repair, and neuroprotection. Molecular Neurobiology, 32, 89–103(2005).  https://doi.org/10.1385/mn:32:1:089.
  6. Bell, S., Cooney, J., Packard, C.J., Caslake, M.J. Deighan, C.J. (2012). The effect of omega-3 fatty acids on the atherogenic lipoprotein phenotype in patients with nephrotic range proteinuria. Clinical Nephrology, 77(6), 445–453 (2012).  https://doi.org/10.5414/cn107450.
  7. Carlson, S.E. (2001). Docosahexaenoic acid and arachidonic acid in infant development. Seminars in Neonatology, 6, 437–449 (2001).  https://doi.org/10.1053/siny.2001.0093.
  8. Carrero, J.J., Martín-Bautista, E., Baró, L., Fonollá, J., Jiménez, J., Boza, J.J., et al. (2005). Efectos cardiovasculares de los ácidos grasos omega-3 y alternativas para incrementar su ingesta. Nutrición Hospitalaria Scielo, 20 (1), 63–69 (2005). doi:10.3305%2Fnutr+hosp.v20in01.3525.Google Scholar
  9. Carrié, I., Guesnet, P., Bourre, J.M., Francès, H. (2000). Diets containing long-chain n-3 polyunsaturated fatty acids affect behaviour differently during development than ageing in mice. British Journal of Nutrition, 83, 439–447 (2000).Google Scholar
  10. Das, U.N. (2003). Long-chain polyunsaturated fatty acids in memory formation and consolidation: further evidence and discussion. Nutrition, 19, 988–993 (2003).  https://doi.org/10.1016/s0899-9007(03)00174-6.
  11. D’Auria, E., Miraglia Del Giudice M., Barberi, S., Mandelli, M., Verduci, E., Leonardi, S., et al. (2014). Omega-3 fatty acids and asthma in children. Allergy and Asthma Proceedings, 35(3), 233–240 (2014).  https://doi.org/10.2500/aap.2014.35.3736.
  12. De la Peña, J.E. (2012). Enfermedad del corazón principal causa de muerte en México. Instituto Mexicano de Seguro Social (IMSS). http://archivo.eluniversal.com.mx/sociedad/2014/enfermedad-corazon-causa-muerte-mexico--1040565.html. Accessed 14 Apr 2018.
  13. Dutta-Roy, A.K. (2000). Transport mechanism for long-chain polyunsaturated fatty acids in the human placenta. The American Journal of Clinical Nutrition, 71, 315S–322S.Google Scholar
  14. Encuesta Nacional de Salud y Nutrición [ENSANUT] (2012). Resultados Nacionales. México: National Institute of Public Health. http://ensanut.insp.mx/doctos/ENSANUT2012_PresentacionOficialCorta_09Nov2012.pdf. Accessed 18 Apr 2017.
  15. Flores, M.L., Hernández, G.M., Guevara, P.M. (2007). Efecto neuroprotector de los ácidos grasos omega-3: hallazgos neurofisiológicos y comportamiento. In M.A. Guevara, M. Hernández, M. Arteaga, M.E. Olvera (Eds.). Aproximaciones al estudio de la funcionalidad cerebral y el comportamiento (pp. 509–538). México: University of Guadalajara.Google Scholar
  16. Gil A., & Gil, M. (2004). Funciones de los ácidos grasos poliinsaturados y oleico durante la gestación, la lactación y la infancia. In J. Mataix., & A. Gil. (Eds.). Libro blanco de los omega-3, los ácidos grasos poliinsaturados Omega 3 y monoinsaturados tipo oleico y su papel en la salud (pp. 82–96). Spain: Editorial Médica Panamericana.Google Scholar
  17. Haast, R.A.M., & Kiliaan, A.J. (2014). Impact of fatty acids on brain circulation, structure and function. Prostaglandins Leukotrienes Essent Fatty Acids, 92, 3–14 (2014).  https://doi.org/10.1016/j.plefa.2014.01.002.
  18. Hartweg, J., Farmer, A.J., Perera, R., Holman, R.R., Neil, H.A.W. (2007). Meta-analysis of the effects of n-3 polyunsaturated fatty acids on lipoproteins and other emerging lipid cardiovascular risk markers in patients with type 2 diabetes. Diabetologia, 50, 1593–1602 (2007).  https://doi.org/10.1007/s00125-007-0695-z.
  19. Haubner, L.Y., Stockard, J.E., Saste, M. D., Benford, V.J., Phelps, C.P., Chen, L.T., et al. (2002). Maternal dietary docosahexanoic acid content affects the rat pup auditory system. Brain Research Bulletin, 58(1), 1–5 (2002).  https://doi.org/10.1016/s0361-9230(01)00764-x.
  20. Helland, I.B., Saugstad, O.D., Saarem, K., Van Houwelingen, A.C., Nylander, G., Drevon, C.A. (2006). Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. The Journal of Maternal-Fetal & Neonatal Medicine, 19(7), 397–406 (2006).  https://doi.org/10.1080/14767050600738396.
  21. Hui-Min, S. (2010). Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry, 21, 364–373 (2010).  https://doi.org/10.1016/j.jnutbio.2009.11.003.
  22. Ikemoto, A., Ohishi, M., Sato, Y., Hata, N., Misawa, Y., Fujii, Y., et al. (2001). Reversibility of n-3 fatty acid deficiency-induced alterations of learning behaviour in the rat: level of n-6 fatty acids as another critical factor. Journal Lipid Research, 42(10), 1655–1663.Google Scholar
  23. Innis, S.M. (2008). Dietary omega 3 fatty acids and the developing brain. Brain Research, 1237, 35–43 (2008).  https://doi.org/10.1016/j.brainres.2008.08.078.
  24. Jalbert, I. (2013). Diet, nutraceuticals and the tear film. Experimental Eye Research, 117,138–146 (2013).  https://doi.org/10.1016/j.exer.2013.08.016.
  25. Kaushik, M., Mozaffarian, D., Spiegelman, D., Manson, J.E., Willett, W.C., Hu, F.B. (2009). Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus. American Journal of Clinical Nutrition, 90 (3), 613–620 (2009).  https://doi.org/10.3945/ajcn.2008.27424.
  26. Krummel, D. (2001). Nutrición en Enfermedades Cardiovasculares. In L. Kathleen, & S. Escott-Stump (Eds.). Nutrición y Dietoterapia de Krause (pp. 525–568). México: Mc Graw-Hill Interamericana (9ª ed.).Google Scholar
  27. Lagercrantz, H., & Ringstedt, T. (2001). Organization of the neuronal circuits in the central nervous system during developing. Acta Paediatrica, 90(7), 707–715 (2001).  https://doi.org/10.1111/j.1651-2227.2001.tb02792.x.
  28. Lee, H., Lee, I.S., Choue, R. (2013). Obesity, Inflammation and Diet. Pediatric Gastroenterology, Hepatology and Nutrition, 16(3), 143–152 (2013).  https://doi.org/10.5223/pghn.2013.16.3.143.
  29. Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., Piette, J. (2014). Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. Biochemical Pharmacology, 92(1), 131–141 (2014).  https://doi.org/10.1016/j.bcp.2014.08.013.
  30. Levan, B., Radel, J.D., Carlson, S.E. (2004). Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. Behavioural Brain Research, 152(1), 49–57 (2004).  https://doi.org/10.1016/j.bbr.2003.09.029.
  31. Mata, P., Alonso, R., Mata, N. (2004). Los omega 3 y los omega 9 en la enfermedad cardiovascular. In J. Mataix., & A. Gil (Eds). Libro blanco de los omega-3, los ácidos grasos poliinsaturados Omega 3 y monoinsaturados tipo oleico y su papel en la salud (pp. 49–63). Spain: Editorial Médica Panamericana.Google Scholar
  32. McCann, J.C., & Ames, B.N. (2005). Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. The American Journal Clinical Nutrition, 82, 281–295.Google Scholar
  33. McNamara, R.K., & Carlson, S.E. (2006). Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukotrienesis and Essential Fatty Acids, 75, 329–349 (2006).  https://doi.org/10.1016/j.plefa.2006.07.010.
  34. Merendino, N. Costantini, L., Manzi, L., Molinari, R., D’Eliseo, D., Velotti, F. (2013) Dietary ω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer. Biochemical Medical Research International, 11, 1–11 (2013).  https://doi.org/10.1155/2013/310186.
  35. Montgomery, C., Speake, B.K., Cameron, A., Sattar, N., Weaver, L.T. (2003). Maternal docosahexaenoic acid supplementation and fetal accretion. The British Journal of Nutrition, 90, 135–145 (2003).  https://doi.org/10.1079/bjn2003888.
  36. Morris, M.C., Evans, D.A., Bienias, J.L., Tangney, C.C., Bennett, D.A., Wilson, R.S., et al. (2003). Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Jama Neurology Formerly Archives of Neurology, 60 (7), 940–946 (2003).  https://doi.org/10.1001/archneur.60.7.940.
  37. Muriana, F. (2004). Metabolismo de los ácidos grasos. In J. Mataix., & A. Gil. (Eds.). Libro blanco de los omega-3, los ácidos grasos poliinsaturados Omega 3 y monoinsaturados tipo oleico y su papel en la salud (pp. 35–47). Spain: Editorial Médica Panamericana.Google Scholar
  38. Nussbaum, R.L., & Ellis, C.E. (2003). Alzheimer’s disease and Parkinson’s disease. The New England Journal of Medicine, 348, 1356–1364 (2003).  https://doi.org/10.1056/nejm2003ra020003.
  39. Organización de las Naciones Unidas para la Agricultura y la Alimentación [FAO] (2009). Visión general del sector pesquero nacional. Japan: FAO. http://www.fao.org/fishery/countrysector/naso_japan/es. Accessed 19 Apr 2017.
  40. Pasinettia, G.M., Wanga, J., Hoa L., Zhao, W., Dubner, L. (2014). Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, 1852, 1202 (2014).  https://doi.org/10.1016/j.bbadis.2014.10.006.
  41. Pirillo, A., & Catapano, A.L. (2013). Omega-3 polyunsaturated fatty acids in the treatment of hypertriglyceridaemia. International Journal of Cardiology, 170, S16–S20 (2013).  https://doi.org/10.1016/j.ijcard.2013.06.040.
  42. Porqueta, D., Griñán-Ferré, C., Ferrerd, I., Caminsa, A., Sanfeliub, C., Del Valle, J., Pallása, M. (2014). Neuroprotective role of trans-resveratrol in a murine model of familial alzheimer’s disease. Journal of Alzheimer’s Disease, 42, 1209–1220 (2014).  https://doi.org/10.3233/jad-140444.
  43. Rahman, M., Beg, S., Ahmad, M.Z., Kazmi, I., Ahmed, A., Rahman, Z., Akhter, S. (2013). Omega-3 fatty acids as pharmacotherapeutics in psoriasis: current status and scope of nanomedicine in its effective delivery. Current Drug Targets, 14(6), 708–722 (2013).  https://doi.org/10.2174/1389450111314060011.
  44. Sanhueza, J., Nieto, S., Valenzuela, A. (2004). Docosahexaenoic acid (DHA), brain development, memory and learning: the importance of perinatal supplementation. Revista Chilena de Nutrición, 31, 138–11 (2004).  https://doi.org/10.4067/s0717-75182004000200002.
  45. Shinto, L., Marracci, G., Baldauf-Wagner, S., Strehlow, A., Yadav, V., Stuber, L., Bourdette, D. (2009). Omega-3 fatty acid supplementation decreases matrix metallopro-teinase-9 production in relapsing-remitting multiple sclerosis. Prostaglandins Leukot Essent Fatty Acids, 80(2–3), 13–136 (2009).  https://doi.org/10.1016/j.plefa.2008.12.001.
  46. Sontrop, J., & Campbell, M.K. (2006). Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. Preventive Medicine, 42, 4–13 (2006).  https://doi.org/10.1016/j.ypmed.2005.11.005.
  47. Swan, K., & Allen, P.J. (2013). Omega-3 fatty acid for the treatment and remission of Crohn’s disease. Journal Complementary and Integrative Medicine, 10, 221–228 (2013).  https://doi.org/10.1515/jcim-2012-0010.
  48. Takeuchi, T., Fukumoto, Y., Harada, E. (2002). Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. Behavioural Brain Research, 131(1–2), 193–203 (2002).  https://doi.org/10.1016/s0166-4328(01)00392-8.
  49. Tanskanen, A., Hibbeln, J.R., Hintikka, J., Haatainen, K., Honkalampi, K., Viinamäki, H. (2001a). Fish consumption, depression, and suicidality in a general population. Jama Psychiatry Formely Archives of General Psychiatry, 58(5), 512–513.Google Scholar
  50. Tanskanen, A., Hibbeln, J.R., Tuomilehto, J., Uutela, A., Haukkala, A., Viinamäki, H. et al. (2001b). Fish consumption and depressive symptoms in the general population in Finland. Psychiatric Services, 52(4), 529–31 (2001).  https://doi.org/10.1176/appi.ps.52.4.529.
  51. Tiemeier, H., Van, H.R., Hofman, A., Kiliaan, A.J., Breteler, M.M. (2003). Plasma fatty acid composition and depression are associated in the elderly: The Rotterdam Study. American Journal of Clinical Nutrition, 78(1), 40–46.Google Scholar
  52. Valenzuela, B.A. (2005). El Salmon: Un Banquete De Salud. Revista Chilena de Nutrición. 32 (1), 8–17 (2005).  https://doi.org/10.4067/s0717-75182005000100001.
  53. Valenzuela, B.R., Tapia, O.G., González E.M., Valenzuela, B.A. (2011a). Omega-3 fatty acids (EPA and DHA) and its application in diverse clinical situations. Revista Chilena de Nutrición, 38 (3), 383–390 (2011).  https://doi.org/10.4067/s0717-75182011000300011.
  54. Valenzuela, B.R., Bascuñan G.K., Chamorro M.R., Valenzuela B.A. (2011b). Ácidos grasos omega-3 y cáncer, una alternativa nutricional para su prevención y tratamiento. Revista Chilena de Nutrición, 38 (2), 219–226 (2011).  https://doi.org/10.4067/s0717-75182011000200012.
  55. Valenzuela, B.R., Bascuñan, G.K., Valenzuela, B.A., Chamorro, M.R. (2009). Omega-3 Fatty Acids, Neurodegenerative and Psychiatric Diseases: A New Preventive and Therapeutic Approach. Revista Chilena de Nutrición, 36 (4), 1120–1128 (2009).  https://doi.org/10.4067/s0717-75182009000400009.
  56. Vasudevan, A., Yu, Y., Banerjee, S., Woods, J., Farhana, L., Rajendra, S.G., et al. (2014). Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer. Cancer Prevention Research, 7(11), 1138–1148 (2014).  https://doi.org/10.1158/1940-6207.capr-14-0177.
  57. Wu, J.H., Micha, R., Imamura, F., Pan, A., Biggs, M.L., Ajaz, et al. (2012). Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis. British Journal of Nutrition, 107 (2), S214–S227 (2012).  https://doi.org/10.1017/s0007114512001602.
  58. Zanarini, M.C., & Frankenburg, F.R. (2003). Omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. The American Journal of Psychiatry, 160(1), 167–169 (2003).  https://doi.org/10.1176/appi.ajp.160.1.167.
  59. Zhou, Y., Tian, C., Jia, C. (2012). Association of fish and n-3 fatty acid intake with the risk of type 2 diabetes: a meta-analysis of prospective studies. British Journal of Nutrition, 108(3), 408–417 (2012).  https://doi.org/10.1017/s0007114512002036.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Psychological Research, Universidad VeracruzanaVeracruzMexico
  2. 2.Food Development and Research UnitInstituto Tecnológico de VeracruzVeracruzMexico

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