Precocious Puberty

  • Madhusmita Misra
  • Sally Radovick


Precocious puberty has been a focus of interest for both the pediatric endocrinologist and the primary pediatrician for many years. The development and application of GnRH agonist (GnRHa) therapy to treat central precocious puberty in the 1980s significantly changed our approach to this disorder. More recently, application of molecular biological techniques has provided us with a better understanding of the intricacies of the regulation of gonadotropin and sex-steroid production characteristic of normal pubertal development and provided us with the tools to elucidate the etiologies of previously uncharacterized disorders of precocious puberty.


Precocious puberty Gonadotropin-releasing hormone (GnRH) GnRH agonist (GnRHa) Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) Androgen Estrogen Central precocious puberty (CPP) Peripheral precocious puberty Gonadotropin-independent precocious puberty 



The editors wish to thank Henry Rodriguez MD and Grace C. Dougan MD for their contributions to this chapter in the prior edition.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pediatric EndocrinologyMassachusetts General Hospital for ChildrenBostonUSA
  2. 2.Pediatrics, Rutgers-Robert Wood Johnson Medical SchoolNew BrunswickUSA

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