Current Trends in Epidemiology and Antimicrobial Resistance in Neonatal Sepsis

  • S. Chavez-Bueno
  • R. J. McCullohEmail author
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Invasive infections are the cause of approximately 25% of deaths in newborns worldwide. In 2015, 336,300 neonatal deaths globally were attributed to sepsis and other neonatal infections [1]. Rates of neonatal sepsis are highest in African countries and lowest in North American and developed European countries. In addition to the different incidence of neonatal invasive disease, the pathogens causing neonatal sepsis and their antibiotic resistance patterns also vary in different regions of the world. This manuscript focuses on the epidemiological characteristics of sepsis in infants younger than 30 days of age in the developed world, and on recent antibiotic resistance trends observed in the pathogens that cause neonatal sepsis in the USA.

Rates of sepsis in newborns are inversely related to gestational age. Neonates rely on innate immune responses as the first line of defense against infections. These mechanisms are impaired in preterm newborns compared to term infants....


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Children’s Mercy Kansas CityKansas CityUSA
  2. 2.University of MissouriKansas CityUSA
  3. 3.University of Kansas Medical CenterKansas CityUSA

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