Systemic Inflammation and Cerebral Dysfunction

  • A. M. Peters van Ton
  • P. Pickkers
  • W. F. AbdoEmail author
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Advances in patient care over recent decades have resulted in lower mortality rates in the intensive care unit (ICU) despite an aging population and increased disease severity. As a consequence, the expanding group of patients who survive critical illness [1] reveals that surviving critical illness is associated with a wide range of long‐lasting negative health outcomes. It is now increasingly recognized that survivors of intensive care may experience physical and cognitive impairment as well as psychological symptoms, which all negatively affect daily functioning and health‐related quality of life.

In 2010, the term ‘post‐intensive care syndrome’ (PCIS) was introduced by the Society of Critical Care Medicine to describe the complex of “new or worsening impairments in physical, cognitive or mental health status arising after critical illness and persisting beyond acute care hospitalization” [ 2]. This term can be applied to both survivors (PICS) and family members of...


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • A. M. Peters van Ton
    • 1
  • P. Pickkers
    • 1
  • W. F. Abdo
    • 1
    Email author
  1. 1.Department of Intensive Care MedicineRadboud University Medical CenterNijmegenNetherlands

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