Advances in Mechanisms, Diagnosis and Treatment of Coagulopathy and Progression of Hemorrhage After Traumatic Brain Injury

  • M. MaegeleEmail author
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Traumatic brain injury (TBI) will surpass many disorders as a principle cause of death and disability by the year 2020 [1]. With approximately 10 million people sustaining a TBI each year, the burden of mortality and morbidity that this entity imposes makes it one of the most challenging health and socioeconomic problems of our times. Recent years have seen changes in the epidemiological pattern of TBI with a shift towards older ages. In these older age groups, falls represent a common cause of TBI, inflicting a higher number of contusional injuries [2]. Although at the moment of impact, disruption of cerebral blood vessels, mainly in the microvasculature, or blood‐brain barrier breakdown is common and results in hemorrhagic lesions, TBI‐associated factors may then alter the intricate balance between bleeding and thrombosis formation in the later sequelae leading to impaired hemostasis, in the following referred to as coagulopathy, with exacerbation of the...


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center (CMMC)University Witten/Herdecke, Campus Cologne-MerheimCologneGermany
  2. 2.Institute for Research in Operative Medicine (IFOM)University Witten/Herdecke, Campus Cologne-MerheimCologneGermany

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