Making Sense of Early High-dose Intravenous Vitamin C in Ischemia/Reperfusion Injury

  • A. M. E. Spoelstra-de ManEmail author
  • P. W. G. Elbers
  • H. M. Oudemans‐van Straaten
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


In Europe, each day over 1,000 patients have a cardiac arrest [1]. Only half of these patients arrive at the hospital alive. Of these survivors, 50% will still die or remain severely disabled due to the post‐cardiac arrest syndrome [2]. Apart from targeted temperature management, there is no effective therapy to improve prognosis. Crucial to the post‐cardiac arrest syndrome is the overwhelming oxidative stress caused by systemic ischemia/reperfusion injury and leading to endothelial dysfunction with cardiovascular failure, brain damage and death. These effects provide a strong rationale for targeting this overwhelming oxidative stress with antioxidant therapy.

Recently, early high‐dose intravenous (i. v.) vitamin C for the treatment of sepsis has attracted a lot of attention in the critical care community as well as in the lay press. The potential benefit of vitamin C, the main circulating antioxidant, has indeed recently been shown in this population. High‐dose...


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • A. M. E. Spoelstra-de Man
    • 1
    Email author
  • P. W. G. Elbers
    • 1
  • H. M. Oudemans‐van Straaten
    • 1
  1. 1.Department of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity InstituteVU University Medical Center AmsterdamAmsterdamNetherlands

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