Lipid Mediators in the Pathogenesis and Resolution of Sepsis and ARDS

  • B. Hamilton
  • L. B. Ware
  • M. A. MatthayEmail author
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Recent research has demonstrated the likely importance of lipid mediators in both the pathogenesis and the resolution of sepsis and the acute respiratory distress syndrome (ARDS) [1, 2, 3]. Compared to cytokines, lipid mediators have been little studied. However, newer methods using mass spectrometry and comprehensive lipidomic analysis have facilitated more detailed investigations into lipid mediator profiles [4]. Use of broad lipid mediator profiling may uncover previously unidentified patterns in a variety of disease processes [3], including sepsis and ARDS.

The first section of this review will describe a relatively new class of lipid molecules that plays a major role in the resolution of acute inflammation and infection, termed specialized pro‐resolving mediators (SPMs). The second section will review evidence that supports an important role for these endogenous lipid mediators in the resolution of localized infections as illustrated in experimental models,...


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Medicine and Division of Allergy, Critical Care and Pulmonary MedicineVanderbilt UniversityNashvilleUSA
  3. 3.Cardiovascular Research InstituteUniversity of CaliforniaSan FranciscoUSA

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