Collagen-Based Scaffolds for Bone Tissue Engineering Applications

  • Madhura P. Nijsure
  • Vipuil Kishore


Over the past three decades, bone tissue engineering (BTE) has garnered significant interest as a potential alternative to autografts and allografts for the repair and regeneration of damaged or diseased bone. BTE entails the use of a viable scaffold, cells and chemical factors to stimulate the formation of functional bone tissue. While a plethora of different materials have been investigated to develop scaffolds for BTE applications, collagen type I is the most extensively studied because it is highly biocompatible, biodegradable, and presents a natural environment to the cells. In this chapter, we present a brief background on BTE and highlight the advantages and limitations of using collagen type I as a biomaterial for BTE applications. Further, we describe the most common scaffold fabrication methodologies that have been employed for the synthesis of collagen-based scaffolds for BTE applications. In vitro and in vivo findings from some of the key studies in the literature that use collagen-based scaffolds for bone repair and regeneration are highlighted. Additionally, advantages and limitations of FDA approved collagen-based scaffolds that are currently used in the clinic for bone applications are also discussed. Finally, some of the current challenges associated with the use of collagen-based scaffolds for BTE applications are identified and areas of future research that have the potential to address these challenges and aid in the development of biomimetic collagen-based scaffolds for the repair and regeneration of functional bone tissue are discussed.


Bone Collagen Scaffolds Biomaterial Tissue engineering Hydrogels Freeze drying Electrospinning Electrochemical fabrication Composites Crosslinking Porosity Alignment In vitro In vivo 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Chemical EngineeringFlorida Institute of TechnologyMelbourneUSA
  2. 2.Department of Biomedical EngineeringFlorida Institute of TechnologyMelbourneUSA

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