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Peptides as Orthopedic Biomaterials

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Orthopedic Biomaterials

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Abstract

Biodegradable metals, including magnesium (Mg), iron (Fe) and zinc (Zn), have been proposed and developed for temporary implants with the expectation to degrade and be absorbed gradually in vivo during the tissue healing process. Compared to Mg alloys and Fe alloys, the standard electrode potential of Zn is between that of Mg and Fe, so its degradation rate has been proved to be more likely in line with the clinical demand. In addition, Zn is one of the essential trace elements in human body and plays essential roles in many enzymes and in cell metabolic activity, proliferation and differentiation. Therefore, the recent progress of Zn-based metallic biomaterials is reviewed in this chapter for the development of high-performance metallic biomaterials.

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Acknowledgement

We acknowledge financial support from AO Foundation (Project S-13-15 L was supported by the AO Foundation), Osteosynthesis & Trauma Care Foundation, the West Virginia National Aeronautics and Space Administration Experimental Program to Stimulate Competitive Research (WV NASA EPSCoR), NIH Grant P20GM103434, and the National Institute of General Medical Sciences of the National Institutes of Health under Award Number 2U54GM104942-02. This work was also supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program, Discovery Award under Award No. W81XWH-17-1-0603. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the funding agencies. C.B., D.A., and Z.W. acknowledge fellowships from WVU Intro program. We thank Suzanne Danley for proofreading.

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Authors and Affiliations

  1. Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA

    Derek E. Andreini, Zachary J. Werner, Christopher D. Bell & Bingyun Li

  2. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

  3. The Children’s Hospital Research Institute of Manitoba, Winnipeg, Canada, MB

    Malcolm Xing

  4. Mary Babb Randolph Cancer Center, Morgantown, WV, USA

    Bingyun Li

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  1. Derek E. Andreini
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  2. Zachary J. Werner
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  3. Christopher D. Bell
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  4. Malcolm Xing
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  5. Bingyun Li
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Correspondence to Bingyun Li .

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Editors and Affiliations

  1. Department of Orthopedics, School of Medicine, West Virginia University, Morgantown, West Virginia, USA

    Bingyun Li

  2. Chemical Engineering, Northeastern University, Boston, Massachusetts, USA

    Thomas Webster

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Andreini, D.E., Werner, Z.J., Bell, C.D., Xing, M., Li, B. (2017). Peptides as Orthopedic Biomaterials. In: Li, B., Webster, T. (eds) Orthopedic Biomaterials. Springer, Cham. https://doi.org/10.1007/978-3-319-73664-8_10

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