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Immunopathogenesis of Myasthenia Gravis

  • Rozen Le Panse
  • Sonia Berrih-Aknin
Chapter
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

The development of myasthenia gravis (MG), similar to the other autoimmune diseases, combines a predisposing genetic background, immune imbalance, and triggering factors. The etiological hypotheses are discussed, and the role of the thymus is detailed in the context of the recent results of the thymectomy trial. The main defects of immune regulation, including the role of B cells, the immune imbalance between Treg and Th17 cells, and the role of follicular helper cells, are reviewed. Together, this book chapter summarizes the heterogeneity of MG patients and the genetic, immunological, and environmental mechanisms that play a potential role in this disease.

Keywords

Myasthenia Autoantibodies Thymus Inflammation Germinal centers Th17 cells Treg cells Tfh cells Viral hypothesis Genetics Environmental factors miRNA 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.La Pitié-SalpêtrièreCenter of Research in MyologyParisFrance

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