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Management of Multiorgan Failure in Sepsis

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Handbook of Sepsis

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Abstract

A complex interaction between host and pathogen determines whether patients with infection will develop sepsis, which is defined by the development of multiorgan failure. Patients’ clinical organ failure phenotype and molecular endotype predict outcome differences. While interventions targeting molecular pathways thought to lead from infection to multiorgan failure have so far proven unsuccessful, strategies focusing on support of specific organs may aid recovery from sepsis-associated multiorgan failure.

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Authors and Affiliations

  1. Intermountain Medical Center, Murray, UT, USA

    Ithan D. Peltan M.D., M.Sc. & Samuel M. Brown M.D., M.S.

  2. University of Utah School of Medicine, Salt Lake City, UT, USA

    Ithan D. Peltan M.D., M.Sc. & Samuel M. Brown M.D., M.S.

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  1. Ithan D. Peltan M.D., M.Sc.
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  2. Samuel M. Brown M.D., M.S.
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  1. University of Amsterdam, Amsterdam, The Netherlands

    W. Joost Wiersinga

  2. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Christopher W. Seymour

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Peltan, I.D., Brown, S.M. (2018). Management of Multiorgan Failure in Sepsis. In: Wiersinga, W., Seymour, C. (eds) Handbook of Sepsis. Springer, Cham. https://doi.org/10.1007/978-3-319-73506-1_10

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