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Adult and Pediatric Neuromodulation pp 13–24Cite as

Neuromodulation for Non-urologic Chronic Pain

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Abstract

Neuromodulation, referring to the targeted electrical or pharmacological modification of nervous system activity, has a decades-long history in the development of unique treatment modalities for chronic pain syndromes. The interventional treatment of pain has gradually shifted from lesional (permanent) to neuromodulatory (reversible). Advances in neuromodulation technology have been most effective in the treatment of neuropathic pain, which is notoriously difficult to treat and refractory to conventional measures. Spinal cord stimulation is the best known and most widely used neuromodulatory treatment modality for chronic pain, although there is great interest in additional paradigms including peripheral nerve stimulation, deep brain stimulation, motor cortex stimulation, and intrathecal drug delivery. As these technologies have matured, the clinical indications have expanded and the technology has become more sophisticated. Accordingly, there exists a high-quality body of evidence to support the use of various neuromodulation devices, based off randomized control trials, prospective and retrospective series, and expert opinion. The aim of this chapter is to provide a brief overview of the most commonly-employed neuromodulation procedures in the treatment of chronic non-urologic pain. The historical origins of these technologies will be discussed alongside the current clinical indications and evidence.

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Authors and Affiliations

  1. Department of Neurological Surgery, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, OH, USA

    Michael D. Staudt & Jonathan P. Miller

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  1. Michael D. Staudt
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  2. Jonathan P. Miller
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Correspondence to Jonathan P. Miller .

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  1. Department of Urology, Oakland University William, Beaumont School of Medicine, Royal Oak, Michigan, USA

    Jason P. Gilleran

  2. Section of Urology, Nationwide Children’s Hospital and The Ohio State Wexner Medical Center, Columbus, Ohio, USA

    Seth A. Alpert

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Staudt, M.D., Miller, J.P. (2018). Neuromodulation for Non-urologic Chronic Pain. In: Gilleran, J., Alpert, S. (eds) Adult and Pediatric Neuromodulation . Springer, Cham. https://doi.org/10.1007/978-3-319-73266-4_2

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  • DOI: https://doi.org/10.1007/978-3-319-73266-4_2

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