Neurocognitive Disorders

  • Rajesh R. Tampi
  • Deena J. Tampi
  • Wynnelena C. Canio
  • Poorvanshi Alag
  • Dhweeja Dasarathy
  • Joel P. Dey
Chapter

Abstract

Mild neurocognitive disorder is thought to be an intermediate stage between normal age-associated cognitive changes and major neurocognitive disorder. Individuals with mild neurocognitive disorder have a faster rate of progression to major neurocognitive disorder than age-matched controls. Known risk factors for progression to major neurocognitive disorder include greater cognitive deficits at baseline, the presence of the APOE4 carrier gene, greater brain volume changes, cerebrospinal fluid changes, and the presence of neuropsychiatric symptoms. Current data indicates that the progression of mild neurocognitive disorder to major neurocognitive disorder can be delayed through the use of cognitive and physical training. Unfortunately, studies of pharmacotherapeutic agents do not indicate any benefit for cholinesterase inhibitors, the anti-inflammatory drug rofecoxib, and antioxidants in slowing the progression of mild neurocognitive disorder to major neurocognitive disorder.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rajesh R. Tampi
    • 1
  • Deena J. Tampi
    • 2
  • Wynnelena C. Canio
    • 3
  • Poorvanshi Alag
    • 1
  • Dhweeja Dasarathy
    • 4
  • Joel P. Dey
    • 5
  1. 1.Case Western Reserve University School of Medicine and MetrohealthClevelandUSA
  2. 2.Diamond HealthcareRichmondUSA
  3. 3.Semel Institute for Neuroscience and Human Behavior, UCLA School of MedicineLos AngelesUSA
  4. 4.Harvard UniversityCambridgeUSA
  5. 5.MetrohealthClevelandUSA

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