Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins

  • Panagiotis Papatheodorou
  • Holger Barth
  • Nigel Minton
  • Klaus Aktories
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1050)

Abstract

Research on the human gut pathogen Clostridium difficile and its toxins has gained much attention, particularly as a consequence of the increasing threat to human health presented by emerging hypervirulent strains. Toxin A (TcdA) and B (TcdB) are the two major virulence determinants of C. difficile. Both are single-chain proteins with a similar multidomain architecture. Certain hypervirulent C. difficile strains also produce a third toxin, namely binary toxin CDT (Clostridium difficile transferase). As C. difficile toxins are the causative agents of C. difficile-associated diseases (CDAD), such as antibiotics-associated diarrhea and pseudomembranous colitis, considerable efforts have been expended to unravel their molecular mode-of-action and the cellular mechanisms responsible for their uptake. Notably, a high proportion of studies on C. difficile toxins were performed in European laboratories. In this chapter we will highlight important recent advances in C. difficile toxins research.

Keywords

Clostridium difficile Bacterial disease Bacterial toxins Toxin uptake Toxin receptor 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Panagiotis Papatheodorou
    • 1
    • 2
    • 3
  • Holger Barth
    • 2
  • Nigel Minton
    • 4
  • Klaus Aktories
    • 1
  1. 1.Institute of Experimental and Clinical Pharmacology and ToxicologyAlbert Ludwig University of FreiburgFreiburg im BreisgauGermany
  2. 2.Institute of Pharmacology and ToxicologyUniversity of Ulm Medical CenterUlmGermany
  3. 3.Faculty of Natural SciencesUniversity of UlmUlmGermany
  4. 4.BBSRC/EPSRC Synthetic Biology Research CentreUniversity of NottinghamNottinghamUK

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