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Faecal Microbiota Transplantation as Emerging Treatment in European Countries

  • Marcello Maida
  • James Mcilroy
  • Gianluca Ianiro
  • Giovanni Cammarota
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1050)

Abstract

Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections in the world and is a leading cause of morbidity and mortality in hospitalized patients.

Although several antibiotics effectively treat CDI, some individuals do not respond to these drugs and may be cured by transplanting stool from healthy donors. This procedure, termed Faecal Microbiota Transplantation (FMT), has demonstrated remarkable efficacy as a treatment for recurrent CDI.

FMT has also been investigated in other diseases and disorders where perturbations to the gut microbiota have been theorized to play a causative role in pathogenesis and severity, such as inflammatory bowel disease (IBD). Although FMT is currently not recommended to cure IBD patients in clinical practice, several studies have recently been carried out with promising results. The aim of future research is therefore to standardize protocols and develop FMT as a therapeutic option for these patients.

This review summarizes data on the use of FMT as a treatment for CDI and IBD, with special attention given to studies conducted in European countries.

Keywords

Clostridium difficile European Faecal microbiota transplantation Fecal Inflammatory bowel disease 

Notes

Conflict-of-Interest Statement

James McIlroy has received personal fees from EnteroBiotix during the conduct of this manuscript.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Marcello Maida
    • 1
  • James Mcilroy
    • 2
  • Gianluca Ianiro
    • 3
  • Giovanni Cammarota
    • 3
  1. 1.Section of GastroenterologyS.Elia – Raimondi HospitalCaltanissettaItaly
  2. 2.School of Medicine, Medical Sciences and NutritionUniversity of AberdeenAberdeenUK
  3. 3.Gastroenterological AreaFondazione Policlinico Universitario Gemelli, Università Cattolica del Sacro CuoreRomeItaly

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