Magnetic Resonance Elastography of the Liver

Chapter

Abstract

Elastography evaluates the intrinsic mechanical viscoelastic properties of liver parenchyma and allow for estimation of liver stiffness (LS), whereby elevated stiffness is associated with presence of advanced fibrosis. Measurement of liver stiffness by magnetic resonance elastography (MRE) has been tested for staging of liver disease in a variety of patients, providing convincing data especially among those with non-alcoholic fatty liver disease. Beyond diagnosis, non-invasive measures may have a prognostic role. Measurement of LS by MRE may serve as a complementary tool to monitor progression of disease. However, clinical algorithms are needed whereby MRE and other non-invasive markers can seamlessly be incorporated in care of patients with CLD, keeping in mind the cost, accessibility and incremental clinical utility offered above and beyond that which may be gained by simple bedside clinical assessment.

Keywords

Transient elastography Magnetic resonance elastography Serum tests Cirrhosis Compensated Decompensated Portal hypertension Prognosis 

References

  1. 1.
    Bell BP, Manos MM, Zaman A, Terrault N, Thomas A, Navarro VJ, et al. The epidemiology of newly diagnosed chronic liver disease in gastroenterology practices in the United States: results from population-based surveillance. Am J Gastroenterol. 2008;103(11):2727–36. quiz 37CrossRefPubMedGoogle Scholar
  2. 2.
    Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40(6):1387–95.CrossRefPubMedGoogle Scholar
  3. 3.
    Kanwal F, Kramer JR, Duan Z, Yu X, White D, El-Serag HB. Trends in the burden of nonalcoholic fatty liver disease in a United States Cohort of Veterans. Clin Gastroenterol Hepatol. 2016;14(2):301–8.e1–2.CrossRefPubMedGoogle Scholar
  4. 4.
    Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84.CrossRefPubMedGoogle Scholar
  5. 5.
    Liu B, Balkwill A, Reeves G, Beral V. Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study. BMJ. 2010;340:c912.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Kim WR, Brown RS Jr, Terrault NA, El-Serag H. Burden of liver disease in the United States: summary of a workshop. Hepatology. 2002;36(1):227–42.CrossRefPubMedGoogle Scholar
  7. 7.
    Muir AJ, Trotter JF. A survey of current liver biopsy practice patterns. J Clin Gastroenterol. 2002;35(1):86–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Standish RA, Cholongitas E, Dhillon A, Burroughs AK, Dhillon AP. An appraisal of the histopathological assessment of liver fibrosis. Gut. 2006;55(4):569–78.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Everhart JE, Wright EC, Goodman ZD, Dienstag JL, Hoefs JC, Kleiner DE, et al. Prognostic value of Ishak fibrosis stage: findings from the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2010;51(2):585–94.CrossRefPubMedGoogle Scholar
  10. 10.
    Muthupillai R, Lomas DJ, Rossman PJ, Greenleaf JF, Manduca A, Ehman RL. Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science. 1995;269(5232):1854–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Yin M, Chen J, Glaser KJ, Talwalkar JA, Ehman RL. Abdominal magnetic resonance elastography. Top Magn Reson Imaging. 2009;20(2):79–87.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Talwalkar JA, Yin M, Fidler JL, Sanderson SO, Kamath PS, Ehman RL. Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications. Hepatology. 2008;47(1):332–42.CrossRefPubMedGoogle Scholar
  13. 13.
    Rouviere O, Yin M, Dresner MA, Rossman PJ, Burgart LJ, Fidler JL, et al. MR elastography of the liver: preliminary results. Radiology. 2006;240(2):440–8.CrossRefPubMedGoogle Scholar
  14. 14.
    Yin M, Talwalkar JA, Glaser KJ, Manduca A, Grimm RC, Rossman PJ, et al. Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol. 2007;5(10):1207–13.e2.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Huwart L, Sempoux C, Salameh N, Jamart J, Annet L, Sinkus R, et al. Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index. Radiology. 2007;245(2):458–66.CrossRefPubMedGoogle Scholar
  16. 16.
    Asbach P, Klatt D, Hamhaber U, Braun J, Somasundaram R, Hamm B, et al. Assessment of liver viscoelasticity using multifrequency MR elastography. Magn Reson Med. 2008;60(2):373–9.CrossRefPubMedGoogle Scholar
  17. 17.
    Crespo S, Bridges M, Nakhleh R, McPhail A, Pungpapong S, Keaveny AP. Non-invasive assessment of liver fibrosis using magnetic resonance elastography in liver transplant recipients with hepatitis C. Clin Transpl. 2013;27(5):652–8.Google Scholar
  18. 18.
    Hennedige TP, Wang G, Leung FP, Alsaif HS, Teo LL, Lim SG, et al. Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B. Gut Liver. 2017;11(3):401–8.CrossRefPubMedGoogle Scholar
  19. 19.
    Singh S, Muir AJ, Dieterich DT, Falck-Ytter YT. American Gastroenterological Association Institute Technical Review on the role of elastography in chronic liver diseases. Gastroenterology. 2017;152(6):1544–77.CrossRefPubMedGoogle Scholar
  20. 20.
    Lee YJ, Lee JM, Lee JE, Lee KB, Lee ES, Yoon JH, et al. MR elastography for noninvasive assessment of hepatic fibrosis: reproducibility of the examination and reproducibility and repeatability of the liver stiffness value measurement. J Magn Reson Imaging. 2014;39(2):326–31.CrossRefPubMedGoogle Scholar
  21. 21.
    Runge JH, Bohte AE, Verheij J, Terpstra V, Nederveen AJ, van Nieuwkerk KM, et al. Comparison of interobserver agreement of magnetic resonance elastography with histopathological staging of liver fibrosis. Abdom Imaging. 2014;39(2):283–90.CrossRefPubMedGoogle Scholar
  22. 22.
    Venkatesh SK, Wang G, Teo LL, Ang BW. Magnetic resonance elastography of liver in healthy asians: normal liver stiffness quantification and reproducibility assessment. J Magn Reson Imaging. 2014;39(1):1–8.CrossRefPubMedGoogle Scholar
  23. 23.
    Lee DH, Lee JM, Han JK, Choi BI. MR elastography of healthy liver parenchyma: normal value and reliability of the liver stiffness value measurement. J Magn Reson Imaging. 2013;38(5):1215–23.CrossRefPubMedGoogle Scholar
  24. 24.
    Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J, et al. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Aliment Pharmacol Ther. 2016;44(3):287–99.CrossRefPubMedGoogle Scholar
  25. 25.
    Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Enomoto N, et al. Magnetic resonance elastography for staging liver fibrosis in chronic hepatitis C. Magn Reson Med Sci. 2012;11(4):291–7.CrossRefPubMedGoogle Scholar
  26. 26.
    Xanthakos SA, Podberesky DJ, Serai SD, Miles L, King EC, Balistreri WF, et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr. 2014;164(1):186–8.CrossRefPubMedGoogle Scholar
  27. 27.
    Schwimmer JB, Behling C, Angeles JE, Paiz M, Durelle J, Africa J, et al. Magnetic resonance elastography measured shear stiffness as a biomarker of fibrosis in pediatric nonalcoholic fatty liver disease. Hepatology. 2017;66(5):1474–85.CrossRefPubMedGoogle Scholar
  28. 28.
    Venkatesh SK, Wang G, Lim SG, Wee A. Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. Eur Radiol. 2014;24(1):70–8.CrossRefPubMedGoogle Scholar
  29. 29.
    Singh S, Venkatesh SK, Wang Z, Miller FH, Motosugi U, Low RN, et al. Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: a systematic review and meta-analysis of individual participant data. Clin Gastroenterol Hepatol. 2015;13(3):440–51.e6.CrossRefPubMedGoogle Scholar
  30. 30.
    Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology. 2014;60(6):1920–8.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Singh S, Venkatesh SK, Loomba R, Wang Z, Sirlin C, Chen J, et al. Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis. Eur Radiol. 2016;26(5):1431–40.CrossRefPubMedGoogle Scholar
  32. 32.
    Eaton JE, Dzyubak B, Venkatesh SK, Smyrk TC, Gores GJ, Ehman RL, et al. Performance of magnetic resonance elastography in primary sclerosing cholangitis. J Gastroenterol Hepatol. 2016;31(6):1184–90.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Schramm C, Eaton J, Ringe KI, Venkatesh S, Yamamura J, MRIwgot IPSCSG. Recommendations on the use of MRI in PSC-A position statement from the International PSC Study Group. Hepatology. 2017;66(5):1675–88.CrossRefPubMedGoogle Scholar
  34. 34.
    Tan CH, Venkatesh SK. Magnetic resonance elastography and other magnetic resonance imaging techniques in chronic liver disease: current status and future directions. Gut Liver. 2016;10(5):672–86.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Venkatesh SK, Ehman RL. Magnetic resonance elastography of liver. Magn Reson Imaging Clin N Am. 2014;22(3):433–46.CrossRefPubMedGoogle Scholar
  36. 36.
    Singh S, Venkatesh SK, Keaveny A, Adam S, Miller FH, Asbach P, et al. Diagnostic accuracy of magnetic resonance elastography in liver transplant recipients: a pooled analysis. Ann Hepatol. 2016;15(3):363–76.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Yoneda M, Thomas E, Sclair SN, Grant TT, Schiff ER. Supersonic shear imaging and transient elastography with the XL probe accurately detect fibrosis in overweight or obese patients with chronic liver disease. Clin Gastroenterol Hepatol. 2015;13(8):1502–9.e5.Google Scholar
  38. 38.
    Cui J, Ang B, Haufe W, Hernandez C, Verna EC, Sirlin CB, et al. Comparative diagnostic accuracy of magnetic resonance elastography vs. eight clinical prediction rules for non-invasive diagnosis of advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease: a prospective study. Aliment Pharmacol Ther. 2015;41(12):1271–80.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Wu WP, Chou CT, Chen RC, Lee CW, Lee KW, Wu HK. Non-invasive evaluation of hepatic fibrosis: the diagnostic performance of magnetic resonance elastography in patients with viral hepatitis B or C. PLoS One. 2015;10(10):e0140068.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Talwalkar JA, Kurtz DM, Schoenleber SJ, West CP, Montori VM. Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2007;5(10):1214–20.CrossRefPubMedGoogle Scholar
  41. 41.
    Friedrich-Rust M, Ong MF, Martens S, Sarrazin C, Bojunga J, Zeuzem S, et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology. 2008;134(4):960–74.CrossRefPubMedGoogle Scholar
  42. 42.
    Huwart L, Sempoux C, Vicaut E, Salameh N, Annet L, Danse E, et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology. 2008;135(1):32–40.CrossRefPubMedGoogle Scholar
  43. 43.
    Bohte AE, de Niet A, Jansen L, Bipat S, Nederveen AJ, Verheij J, et al. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol. 2014;24(3):638–48.CrossRefPubMedGoogle Scholar
  44. 44.
    Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, et al. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology. 2017;152(3):598–607.e2.CrossRefPubMedGoogle Scholar
  45. 45.
    Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, et al. Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease than transient elastography. Gastroenterology. 2016;150(3):626–37.e7.CrossRefPubMedGoogle Scholar
  46. 46.
    Xiao G, Zhu S, Xiao X, Yan L, Yang J, Wu G. Comparison of laboratory tests, ultrasound, or MRE to detect fibrosis in patients with non-alcoholic fatty liver disease: a meta-analysis. Hepatology. 2017;66(5):1486–501.CrossRefPubMedGoogle Scholar
  47. 47.
    Yoon JH, Lee JM, Woo HS, Yu MH, Joo I, Lee ES, et al. Staging of hepatic fibrosis: comparison of magnetic resonance elastography and shear wave elastography in the same individuals. Korean J Radiol. 2013;14(2):202–12.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, et al. Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: a prospective study. Hepatology. 2016;63(2):453–61.CrossRefPubMedGoogle Scholar
  49. 49.
    Castera L, Bedossa P. How to assess liver fibrosis in chronic hepatitis C: serum markers or transient elastography vs. liver biopsy? Liver Int. 2011;31(Suppl 1):13–7.CrossRefPubMedGoogle Scholar
  50. 50.
    Talwalkar JA. Elastography for detecting hepatic fibrosis: options and considerations. Gastroenterology. 2008;135(1):299–302.CrossRefPubMedPubMedCentralGoogle Scholar
  51. 51.
    Castera L, Foucher J, Bernard PH, Carvalho F, Allaix D, Merrouche W, et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology. 2010;51(3):828–35.PubMedGoogle Scholar
  52. 52.
    Hines CD, Bley TA, Lindstrom MJ, Reeder SB. Repeatability of magnetic resonance elastography for quantification of hepatic stiffness. J Magn Reson Imaging. 2010;31(3):725–31.CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    Arena U, Vizzutti F, Corti G, Ambu S, Stasi C, Bresci S, et al. Acute viral hepatitis increases liver stiffness values measured by transient elastography. Hepatology. 2008;47(2):380–4.CrossRefPubMedGoogle Scholar
  54. 54.
    Sagir A, Erhardt A, Schmitt M, Haussinger D. Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology. 2008;47(2):592–5.CrossRefPubMedGoogle Scholar
  55. 55.
    Millonig G, Reimann FM, Friedrich S, Fonouni H, Mehrabi A, Buchler MW, et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. Hepatology. 2008;48(5):1718–23.CrossRefPubMedGoogle Scholar
  56. 56.
    Millonig G, Friedrich S, Adolf S, Fonouni H, Golriz M, Mehrabi A, et al. Liver stiffness is directly influenced by central venous pressure. J Hepatol. 2010;52(2):206–10.CrossRefPubMedGoogle Scholar
  57. 57.
    Chang PE, Miquel R, Blanco JL, Laguno M, Bruguera M, Abraldes JG, et al. Idiopathic portal hypertension in patients with HIV infection treated with highly active antiretroviral therapy. Am J Gastroenterol. 2009;104(7):1707–14.CrossRefPubMedGoogle Scholar
  58. 58.
    Kayadibi H, Sertoglu E, Uyanik M. Biochemical markers, liver biopsy, or magnetic resonance elastography to detect or exclude advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2015;62(1):324–5.CrossRefPubMedGoogle Scholar
  59. 59.
    Crossan C, Tsochatzis EA, Longworth L, Gurusamy K, Davidson B, Rodriguez-Peralvarez M, et al. Cost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation. Health Technol Assess. 2015;19(9):1–409. v–viCrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Bureau C, Metivier S, Peron JM, Selves J, Robic MA, Gourraud PA, et al. Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Aliment Pharmacol Ther. 2008;27(12):1261–8.CrossRefPubMedGoogle Scholar
  61. 61.
    Burroughs AK, Thalheimer U. Hepatic venous pressure gradient in 2010: optimal measurement is key. Hepatology. 2010;51(6):1894–6.CrossRefPubMedGoogle Scholar
  62. 62.
    Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology. 2004;39(2):280–2.CrossRefPubMedGoogle Scholar
  63. 63.
    Lemoine M, Katsahian S, Ziol M, Nahon P, Ganne-Carrie N, Kazemi F, et al. Liver stiffness measurement as a predictive tool of clinically significant portal hypertension in patients with compensated hepatitis C virus or alcohol-related cirrhosis. Aliment Pharmacol Ther. 2008;28(9):1102–10.CrossRefPubMedGoogle Scholar
  64. 64.
    Vizzutti F, Arena U, Romanelli RG, Rega L, Foschi M, Colagrande S, et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. 2007;45(5):1290–7.CrossRefPubMedGoogle Scholar
  65. 65.
    Lim JK, Groszmann RJ. Transient elastography for diagnosis of portal hypertension in liver cirrhosis: is there still a role for hepatic venous pressure gradient measurement? Hepatology. 2007;45(5):1087–90.CrossRefPubMedGoogle Scholar
  66. 66.
    Castera L, Le Bail B, Roudot-Thoraval F, Bernard PH, Foucher J, Merrouche W, et al. Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores. J Hepatol. 2009;50(1):59–68.CrossRefPubMedGoogle Scholar
  67. 67.
    Gharib AM, Han MAT, Meissner EG, Kleiner DE, Zhao X, McLaughlin M, et al. Magnetic resonance elastography shear wave velocity correlates with liver fibrosis and hepatic venous pressure gradient in adults with advanced liver disease. Biomed Res Int. 2017;2017:2067479.CrossRefPubMedPubMedCentralGoogle Scholar
  68. 68.
    Sun HY, Lee JM, Han JK, Choi BI. Usefulness of MR elastography for predicting esophageal varices in cirrhotic patients. J Magn Reson Imaging. 2014;39(3):559–66.CrossRefPubMedGoogle Scholar
  69. 69.
    Talwalkar JA, Yin M, Venkatesh S, Rossman PJ, Grimm RC, Manduca A, et al. Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension. AJR Am J Roentgenol. 2009;193(1):122–7.CrossRefPubMedPubMedCentralGoogle Scholar
  70. 70.
    Fleming KM, Aithal GP, Card TR, West J. All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study. Liver Int. 2012;32(1):79–84.CrossRefPubMedGoogle Scholar
  71. 71.
    Singh S, Fujii LL, Murad MH, Wang Z, Asrani S, Ehman R, et al. Liver stiffness measurement predicts risk of decompensation, hepatocellular cancer and mortality in patients with chronic liver diseases: a systematic review and meta-analysis. Hepatology. 2013;58:956A.CrossRefGoogle Scholar
  72. 72.
    Asrani SK, Talwalkar JA, Kamath PS, Shah VH, Saracino G, Jennings L, et al. Role of magnetic resonance elastography in compensated and decompensated liver disease. J Hepatol. 2014;60(5):934–9.CrossRefPubMedGoogle Scholar
  73. 73.
    Takamura T, Motosugi U, Ichikawa S, Sano K, Morisaka H, Ichikawa T, et al. Usefulness of MR elastography for detecting clinical progression of cirrhosis from child-pugh class a to B in patients with type C viral hepatitis. J Magn Reson Imaging. 2016;44(3):715–22.CrossRefPubMedGoogle Scholar
  74. 74.
    Low G, Owen NE, Joubert I, Patterson AJ, Graves MJ, Alexander GJ, et al. Magnetic resonance elastography in the detection of hepatorenal syndrome in patients with cirrhosis and ascites. Eur Radiol. 2015;25(10):2851–8.CrossRefPubMedGoogle Scholar
  75. 75.
    Abe H, Midorikawa Y, Mitsuka Y, Aramaki O, Higaki T, Matsumoto N, et al. Predicting postoperative outcomes of liver resection by magnetic resonance elastography. Surgery. 2017;162(2):248–55.CrossRefPubMedGoogle Scholar
  76. 76.
    Crespo G, Lens S, Gambato M, Carrion JA, Marino Z, Londono MC, et al. Liver stiffness 1 year after transplantation predicts clinical outcomes in patients with recurrent hepatitis C. Am J Transplant. 2014;14(2):375–83.CrossRefPubMedGoogle Scholar
  77. 77.
    Kamphues C, Klatt D, Bova R, Yahyazadeh A, Bahra M, Braun J, et al. Viscoelasticity-based magnetic resonance elastography for the assessment of liver fibrosis in hepatitis C patients after liver transplantation. RoFo. 2012;184(11):1013–9.CrossRefPubMedGoogle Scholar
  78. 78.
    Lee VS, Miller FH, Omary RA, Wang Y, Ganger DR, Wang E, et al. Magnetic resonance elastography and biomarkers to assess fibrosis from recurrent hepatitis C in liver transplant recipients. Transplantation. 2011;92(5):581–6.CrossRefPubMedGoogle Scholar
  79. 79.
    Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, et al. Weight loss decreases magnetic resonance elastography estimated liver stiffness in nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2017;15(3):463–4.CrossRefPubMedGoogle Scholar
  80. 80.
    D’Ambrosio R, Aghemo A, Fraquelli M, Rumi MG, Donato MF, Paradis V, et al. The diagnostic accuracy of Fibroscan for cirrhosis is influenced by liver morphometry in HCV patients with a sustained virological response. J Hepatol. 2013;59(2):251–6.CrossRefPubMedGoogle Scholar
  81. 81.
    Venkatesh SK, Yin M, Glockner JF, Takahashi N, Araoz PA, Talwalkar JA, et al. MR elastography of liver tumors: preliminary results. AJR Am J Roentgenol. 2008;190(6):1534–40.CrossRefPubMedPubMedCentralGoogle Scholar
  82. 82.
    Motosugi U, Ichikawa T, Koshiishi T, Sano K, Morisaka H, Ichikawa S, et al. Liver stiffness measured by magnetic resonance elastography as a risk factor for hepatocellular carcinoma: a preliminary case-control study. Eur Radiol. 2013;23(1):156–62.CrossRefPubMedGoogle Scholar
  83. 83.
    Anaparthy R, Talwalkar JA, Yin M, Roberts LR, Fidler JL, Ehman RL. Liver stiffness measurement by magnetic resonance elastography is not associated with developing hepatocellular carcinoma in subjects with compensated cirrhosis. Aliment Pharmacol Ther. 2011;34(1):83–91.CrossRefPubMedPubMedCentralGoogle Scholar
  84. 84.
    Garteiser P, Doblas S, Daire JL, Wagner M, Leitao H, Vilgrain V, et al. MR elastography of liver tumours: value of viscoelastic properties for tumour characterisation. Eur Radiol. 2012;22(10):2169–77.CrossRefPubMedGoogle Scholar
  85. 85.
    Oki E, Kakeji Y, Taketomi A, Yamashita Y, Ohgaki K, Harada N, et al. Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis. J Gastrointest Cancer. 2008;39(1–4):82–5.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of MedicineHepatology, Bylor University Medical CenterDallasUSA
  2. 2.Department of MedicineMayo Clinic College of MedicineRochesterUSA

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