Abstract
Despite evidence of acute traumatic coagulopathy hiding in plain site for decades, coagulopathy after trauma was thought to result from the iatrogenic effects of otherwise well-intentioned resuscitation. The luminary shock research of the late 1960s and early 1970s combined with advances in blood banking result in a cold red blood cell and crystalloid-based resuscitation practice which prevailed for decades. Indeed, the initial groundbreaking work on hemorrhagic shock revealed that shocked patients required both oxygen carrying capacity and blood flow (pressure) for survival [1–3]. While much of this early work was done in the era of whole blood, this was largely forgotten as a result of the contemporaneously timed move away from whole blood transfusion toward component therapy. Beginning in the mid-1970s, the blood banking community realized that they could component separate whole blood thereby taking a unit of whole blood and converting it to components; one unit of packed red blood cells (PRBCs) one unit of fresh frozen plasma (FFP) some part of a unit of platelets with the remainder becoming cryoprecipitate consisting of concentrated factors and fibrinogen. The white blood cells were spun or filtered off variably during the process. These changes which were initially made for resource allocation and financial reasons were solidified in the early 1980s by the emergence of HIV and concerns about the safety of the blood supply. Hence the new understanding from research on shock that our patients need oxygen carrying capacity and flow and left with components in the blood bank and crystalloid on the shelf our resuscitation practices evolved toward the delivery of large volumes of cold packed red blood cells and many liters of salt water. It was for decades common to resuscitate severely injured patients with multiple units of packed red blood cells and many liters of crystalloid with little to no attention paid to coagulation measures or any need for plasma or platelets. These resuscitation practices resulted in the creation of or exacerbation of iatrogenic coagulopathy characterized by dilution, hypothermia, and acidosis described below.
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References
Carrico CJ, Coln CD, Lightfoot SA, Allsman A, Shires GT. Extracellular fluid volume replacement in hemorrhagic shock. Surg Forum. 1963;14:10–2.
Shires T, Carrico CJ. Current status of the shock problem. Curr Probl Surg. 1966;3:3–67.
Shires T, Coln D, Carrico J, Lightfoot S. Fluid therapy in hemorrhagic shock. Arch Surg. 1964;88:688–93.
Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127–30.
MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39–44.
Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13(6):680–5.
Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63(6):1254–61; discussion 61–2
Cohen MJ, Kutcher M, Redick B, Nelson M, Call M, Knudson MM, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S40–7.
Kutcher ME, Ferguson AR, Cohen MJ. A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg. 2013;74(5):1223–9; discussion 9–30
Kutcher ME, Howard BM, Sperry JL, Hubbard AE, Decker AL, Cuschieri J, et al. Evolving beyond the vicious triad: differential mediation of traumatic coagulopathy by injury, shock, and resuscitation. J Trauma Acute Care Surg. 2015;78(3):516–23.
Esmon CT. The protein C pathway. Chest. 2003;124(3 Suppl):26S–32S.
Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 2015;125(19):2898–907.
Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255(2):379–85.
Howard BM, Miyazawa BY, Dong W, Cedron WJ, Vilardi RF, Ruf W, et al. The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury. J Trauma Acute Care Surg. 2015;79(6):1009–13; discussion 1014.
Johansson PI, Bochsen L, Stensballe J, Secher NH. Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG). Transfus Apher Sci. 2008;39(1):3–8.
Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, et al. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014;77(6):811–7; discussion 7
Moore HB, Moore EE, Liras IN, Gonzalez E, Harvin JA, Holcomb JB, et al. Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients. J Am Coll Surg. 2016;222(4):347–55.
Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, et al. Postinjury fibrinolysis shutdown: rationale for selective tranexamic acid. J Trauma Acute Care Surg. 2015;78(6 Suppl 1):S65–9.
Moore HB, Moore EE, Lawson PJ, Gonzalez E, Fragoso M, Morton AP, et al. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery. 2015;158(2):386–92.
Menezes AA, Vilardi RF, Arkin AP, Cohen MJ. Targeted clinical control of trauma patient coagulation through a thrombin dynamics model. Sci Transl Med. 2017;9(371)
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Cohen, M.J. (2018). Coagulation Perturbations After Severe Injury: Translational Approaches and the State of the Science. In: Duchesne, J., Inaba, K., Khan, M. (eds) Damage Control in Trauma Care. Springer, Cham. https://doi.org/10.1007/978-3-319-72607-6_18
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