Cutaneous Autoimmune Connective Tissue Disorders
Gender has a significant influence on the development of autoimmune diseases whereby in general, women are more susceptible than men. The established striking predominance in females in most of cutaneous collagen disorders such as Systemic Lupus Erythematosus, Systemic Sclerosis or Siogren Syndrome is related mainly to the complex interactions of sex hormones and the immune system.
Despite the increased awareness and significant progress in research detailed in this review, there is still a gap of reference to gender in some skin specific autoimmune disorders investigated, providing challenging future goals.
KeywordsFemale predominance Gender dimorphism Immunologic hormonal interface Multifactorial pathogenesis Environmental and lifestyle induced autoimmunity
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