Aging of the Skin

  • Enzo BerardescaEmail author
  • Norma Cameli
  • Maria Mariano


Skin aging is the progressive skin loss of function due to intrinsic and extrinsic factors which have effects on both epidermis and dermis. Epidermal thinning and increased catabolic activity due to MMP expression cause loss of collagen and wrinkle formation. UV light and other factors such as pollution play a fundamental role in photoaging. In women, menopause and oestrogen decay can further increase the dermal decay of collagen and hyaluronic acid aging worsening the aging process.


UV light Stratum corneum Pollution Metalloproteinases (MMP) Hyaluronic acid (HA) Collagen Skin microcirculation Corneocyte Dermal extracellular matrix (ECM) 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.San Gallicano Dermatological InstituteRomeItaly

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