Melanocytic Nevi: Patterns and Gender Differences

  • Miryam Kerner


Melanocytic nevi encompass a variety of lesions including congenital melanocytic nevi, acquired melanocytic nevi, blue nevi, and Spitz nevi. These nevi can occasionally manifest gender differences depending on the different life cycles of the women versus the men and the unique anatomic differences.


Gender Nevus Melanoma 



Acquired melanocytic nevi


Atypical melanocytic nevi of the genital type


Congenital melanocytic nevus


Dermo-epidermal junction


Estrogen receptor beta


The study of nevi in children


Conflict of Interest

The author has no conflict of interest to declare.


  1. 1.
    Price HN, Schaffer JV. Congenital melanocytic nevi-when to worry and how to treat: facts and controversies. Clin Dermatol. 2010;28:293–302.CrossRefGoogle Scholar
  2. 2.
    Rhodes AR, Albert LS, Weinstock MA. Congenital nevomelanocytic nevi: proportionate area expansion during infancy and early childhood. J Am Acad Dermatol. 1996;34:51–62.CrossRefGoogle Scholar
  3. 3.
    Consensus conference: precursors to malignant melanoma. JAMA. 1984;251:1864–66.Google Scholar
  4. 4.
    Slutsky JB, Barr JM, Femia AN, Marghoob AA. Large congenital melanocytic nevi: associated risks and management considerations. Semin Cutan Med Surg. 2010;29:79–84.CrossRefGoogle Scholar
  5. 5.
    Kovalyshyn I, Braun R, Marghoob A. Congenital melanocytic naevi. Australas J Dermatol. 2009;50:231–40; quiz 241-232.CrossRefGoogle Scholar
  6. 6.
    Marghoob AA, Braun RP, Kopf AW. Atlas of dermoscopy. Abingdon: Taylor and Francis; 2005.Google Scholar
  7. 7.
    Changchien L, Dusza SW, Agero AL, Korzenko AJ, Braun RP, Sachs D, et al. Age- and site-specific variation in the dermoscopic patterns of congenital melanocytic nevi: an aid to accurate classification and assessment of melanocytic nevi. Arch Dermatol. 2007;143:1007–14.CrossRefGoogle Scholar
  8. 8.
    Minagawa A, Koga H, Saida T. Dermoscopic characteristics of congenital melanocytic nevi affecting acral volar skin. Arch Dermatol. 2011;147:809–13.CrossRefGoogle Scholar
  9. 9.
    Haliasos EC, Kerner M, Jaimes N, Zalaudek I, Malvehy J, Hofmann-Wellenhof R, et al. Dermoscopy for the pediatric dermatologist part III: dermoscopy of melanocytic lesions. Pediatr Dermatol. 2013;30(3):281–93.CrossRefGoogle Scholar
  10. 10.
    Stinco G, Argenziano G, Favot F, Valent F, Patrone P. Absence of clinical and dermoscopic differences between congenital and noncongenital melanocytic naevi in a cohort of 2-year-old children. Br J Dermatol. 2011;165:1303–7.CrossRefGoogle Scholar
  11. 11.
    Oliveria SA, Geller AC, Dusza SW, Marghoob AA, Sachs D, Weinstock MA, et al. The Framingham school nevus study: a pilot study. Arch Dermatol. 2004;140(5):545–51.CrossRefGoogle Scholar
  12. 12.
    Zalaudek I, Grinschgl S, Argenziano G, Marghoob AA, Blum A, Richtig E, et al. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol. 2006;154:299–304.CrossRefGoogle Scholar
  13. 13.
    Zalaudek I, Hofmann-Wellenhof R, Kittler H, Argenziano G, Ferrara G, Petrillo L, et al. A dual concept of nevogenesis: theoretical considerations based on dermoscopic features of melanocytic nevi. J Dtsch Dermatol Ges. 2007;5:985–92.CrossRefGoogle Scholar
  14. 14.
    Scope A, Marghoob AA, Dusza SW, Satagopan JM, Agero AL, Benvenuto-Andrade C, et al. Dermoscopic patterns of naevi in fifth grade children of the Framingham school system. Br J Dermatol. 2008;158:1041–9.CrossRefGoogle Scholar
  15. 15.
    Aguilera P, Puig S, Guilabert A, Julia M, Romero D, Vicente A, et al. Prevalence study of nevi in children from Barcelona. Dermoscopy, constitutional and environmental factors. Dermatology. 2009;218:203–14.CrossRefGoogle Scholar
  16. 16.
    Zalaudek I, Schmid K, Marghoob AA, Scope A, Manzo M, Moscarella E, et al. Frequency of dermoscopic nevus subtypes by age and body site: a cross-sectional study. Arch Dermatol. 2011;147:663–70.CrossRefGoogle Scholar
  17. 17.
    Fonseca M, Marchetti MA, Chung E, Dusza SW, Burnett ME, Marghoob AA, et al. Cross-sectional analysis of the dermoscopic patterns and structures of melanocytic naevi on the back and legs of adolescents. Br J Dermatol. 2015;173(6):1486–93.CrossRefGoogle Scholar
  18. 18.
    Barnhill RL, Rabinovitz HS. Benign melanocytic neoplasms. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. Basel: Mosby; 2007. p. 1722–3.Google Scholar
  19. 19.
    Schaffer JV. Pigmented lesions in children: when to worry. Curr Opin Pediatr. 2007;19:430–40.CrossRefGoogle Scholar
  20. 20.
    Larsson PA, Liden S. Prevalence of skin diseases among adolescents 12–16 years of age. Acta Derm Venereol. 1980;60:415–23.Google Scholar
  21. 21.
    Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997;37:620–4.CrossRefGoogle Scholar
  22. 22.
    Kolm I, Di Stefani A, Hofmann-Wellenhof R, Fink-Puches R, Wolf IH, Richtig E, et al. Dermoscopy patterns of halo nevi. Arch Dermatol. 2006;142:1627–32.CrossRefGoogle Scholar
  23. 23.
    Kerner M, Jaimes N, Scope A, Marghoob AA. Spitz nevi: a bridge between dermoscopic morphology and histopathology. Dermatol Clin. 2013;31(2):327–35.CrossRefGoogle Scholar
  24. 24.
    Cesinaro AM, Foroni M, Sighinolfi P, Migaldi M, Trentini GP. Spitz nevus is relatively frequent in adults: a clinico-pathologic study of 247 cases related to patient’s age. Am J Dermatopathol. 2005;27(6):469–75.CrossRefGoogle Scholar
  25. 25.
    Soyer HP, Argenziano G, Hofmann-Wellenhof R, Johr RH. Color atlas of melanocytic lesions of the skin. New York: Springer; 2007.CrossRefGoogle Scholar
  26. 26.
    Pellacani G, Longo C, Ferrara G, Cesinaro AM, Bassoli S, Guitera P, et al. Spitz nevi: in vivo confocal microscopic features, dermatoscopic aspects, histopathologic correlates, and diagnostic significance. J Am Acad Dermatol. 2009;60:236–47.CrossRefGoogle Scholar
  27. 27.
    Scope A, Marchetti MA, Marghoob AA, Dusza SW, Geller AC, Satagopan JM, et al. The study of nevi in children: principles learned and implications for melanoma diagnosis. J Am Acad Dermatol. 2016;75(4):813–23.CrossRefGoogle Scholar
  28. 28.
    Gandini S, Sera F, Cattaruzza MS, Pasquini P, Abeni D, Boyle P, et al. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer. 2005;41(1):28–44.CrossRefGoogle Scholar
  29. 29.
    Oliveria SA, Satagopan JM, Geller AC, Dusza SW, Weinstock MA, Berwick M, et al. Study of nevi in children (SONIC): baseline findings and predictors of nevus count. Am J Epidemiol. 2009;169(1):41–53.CrossRefGoogle Scholar
  30. 30.
    English DR, Armstrong BK. Melanocytic nevi in children. I. Anatomic sites and demographic and host factors. Am J Epidemiol. 1994;139(4):390–401.CrossRefGoogle Scholar
  31. 31.
    Dwyer T, Blizzard L, Ashbolt R. Sunburn associated with increased number of nevi in darker as well as lighter skinned adolescents of northern European descent. Cancer epidemiology and prevention. Biomarkers. 1995;4(8):825–30.Google Scholar
  32. 32.
    Nading MA, Nanney LB, Ellis DL. Pregnancy and estrogen receptor beta expression in a large congenital nevus. Arch Dermatol. 2009;145(6):691–4.CrossRefGoogle Scholar
  33. 33.
    Wrone DA, Duncan LM, Sober AJ. Melanoma and pregnancy: eight questions with discussion. J Gend Specif Med. 1999;2(4):52–4.Google Scholar
  34. 34.
    Bieber AK, Martires KJ, Driscoll MS, Grant-Kels JM, Pomeranz MK, Stein JA. Nevi and pregnancy. J Am Acad Dermatol. 2016;75(4):661–6.CrossRefGoogle Scholar
  35. 35.
    Rubegni P, Sbano P, Burroni M, Cevenini G, Bocchi C, Severi FM, et al. Melanocytic skin lesions and pregnancy: digital dermoscopy analysis. Skin Res Technol. 2007;13(2):143–7.CrossRefGoogle Scholar
  36. 36.
    Nading MA, Nanney LB, Boyd AS, Ellis DL. Estrogen receptor beta expression in nevi during pregnancy. Exp Dermatol. 2008;17(6):489–97.CrossRefGoogle Scholar
  37. 37.
    Ellis DL, Wheeland RG. Increased nevus estrogen and progesterone ligand binding related to oral contraceptives or pregnancy. J Am Acad Dermatol. 1986;14(1):25–31.CrossRefGoogle Scholar
  38. 38.
    Travers RL, Sober AJ, Berwick M, Mihm MC Jr, Barnhill RL, Duncan LM. Increased thickness of pregnancy-associated melanoma. Br J Dermatol. 1995;132(6):876–83.CrossRefGoogle Scholar
  39. 39.
    Rongioletti F, Urso C, Batolo D, Chimenti S, Fanti PA, Filotico R, et al. Melanocytic nevi of the breast: a histologic case-control study. J Cutan Pathol. 2004;31(2):137–40.CrossRefGoogle Scholar
  40. 40.
    Nicolau AA, Aşchie M. Morphologic and immunohistochemical features of breast nevi. Rom J Morphol Embryol. 2013;54(2):371–5.Google Scholar
  41. 41.
    Merkel EA, Martini MC, Amin SM, Lee CY, Gerami P. Evaluation of dermoscopic features for distinguishing melanoma from special site nevi of the breast. J Am Acad Dermatol. 2016;75(2):364–70.CrossRefGoogle Scholar
  42. 42.
    Ahn CS, Guerra A, Sangüeza OP. Melanocytic nevi of special sites. Am J Dermatopathol. 2016;38(12):867–81. ReviewCrossRefGoogle Scholar
  43. 43.
    Kolm I, Kamarashev J, Kerl K, Mainetti C, Giovanoli P, French LE, et al. Diagnostic pitfall: pigmented lesion of the nipple—correlation between dermoscopy, reflectance confocal microscopy and histopathology. Dermatology. 2011;222(1):1–4.CrossRefGoogle Scholar
  44. 44.
    Happle R. The Bork-Baykal phenomenon: a revised eponymic designation for the sparing of nipple and areola in large melanocytic nevi involving the breast. J Eur Acad Dermatol Venereol. 2017;31:e214.CrossRefGoogle Scholar
  45. 45.
    Baykal C, Solakoğlu S, Polat Ekinci A, Yazganoğlu KD. Large congenital melanocytic nevus on the breast sparing the nipple and areola. Pediatr Dermatol. 2015;32(4):514–7.CrossRefGoogle Scholar
  46. 46.
    Ribé A. Melanocytic lesions of the genital area with attention given to atypical genital nevi. J Cutan Pathol. 2008;35(s2):24–7.CrossRefGoogle Scholar
  47. 47.
    Val-Bernal JF, Val D, Garijo MF. Clinically unapparent melanocytic nevi on the prepuce. J Cutan Pathol. 2009;36(4):444–7.CrossRefGoogle Scholar
  48. 48.
    Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D. Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review. J Am Acad Dermatol. 2014;71(6):1241–9.CrossRefGoogle Scholar
  49. 49.
    Blum A, Simionescu O, Argenziano G, Braun R, Cabo H, Eichhorn A, et al. Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: results of a multicenter study by the International Dermoscopy Society (IDS). Arch Dermatol. 2011;147(10):1181–7.CrossRefGoogle Scholar
  50. 50.
    Rogers T, Pulitzer M, Marino ML, Marghoob AA, Zivanovic O, Marchetti MA. Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria? Dermatol Pract Concept. 2016;6(4):43–6.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyHaEmek Medical CenterAfulaIsrael
  2. 2.Rappaport Faculty of MedicineTechnion – Israel Institute of TechnologyHaifaIsrael

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