Hematologic Disease in Implantation Failure

  • Shelby A. Neal
  • Jason M. Franasiak
  • Richard T. Scott


Successful embryo implantation involves a number of events that occur at the microvascular level. Hematologic pathology, specifically inherited and acquired thrombophilias, has been proposed as a potential etiology for implantation failure. This idea has largely evolved from the robust body of literature surrounding thrombophilias and recurrent pregnancy loss. The impact of thrombophilias on recurrent implantation failure is less clear, although it is thought to have a similar underlying mechanism, namely, that microthrombosis causes disturbed blood flow to the endometrium and, in the case of recurrent implantation failure, impairs the initial vascularization process that is necessary for successful implantation to occur. In this chapter, the available literature regarding the potential role of thrombophilias in implantation failure and the evidence for possible therapeutic options will be reviewed.


Inherited thrombophilia Acquired thrombophilia Recurrent implantation failure 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shelby A. Neal
    • 1
    • 2
  • Jason M. Franasiak
    • 1
    • 2
  • Richard T. Scott
    • 1
    • 2
  1. 1.Sidney Kimmel Medical CollegeThomas Jefferson University PhiladelphiaPhiladelphiaUSA
  2. 2.IVI-RMA of New JerseyBasking RidgeUSA

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