Fungal Inteins: Distribution, Evolution, and Applications

  • Skander Elleuche
  • Stefanie PöggelerEmail author
Part of the The Mycota book series (MYCOTA, volume 15)


Inteins are internal in-frame insertions transcribed and translated together with their host protein and excised at the protein level. The posttranslational process that excises the intein from a precursor protein with subsequent ligation of the flanking protein fragments, called N- and C-exteins, is termed protein splicing. Inteins have predominantly been identified in prokaryotes but are also found in fungal genomes. The growing number of fully sequenced fungal genomes encourages computer-aided identification in diverse species. This review gives an update on fungal inteins that includes the characteristics, as well as the distribution of fungal inteins. It summarizes the recent progress in understanding the protein splicing mechanism, discusses intein evolution, and gives an overview how fungal inteins can be used for technical applications.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Miltenyi Biotec GmbHBergisch GladbachGermany
  2. 2.Abteilung Genetik eukaryotischer MikroorganismenInstitut für Mikrobiologie und Genetik, Georg-August-Universität GöttingenGöttingenGermany
  3. 3.Göttingen Center for Molecular Biosciences (GZMB)Georg-August-University GöttingenGöttingenGermany

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