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Helminth Electron Transport Inhibitors Produced by Fungi

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Book cover Physiology and Genetics

Part of the book series: The Mycota ((MYCOTA,volume 15))

Abstract

The electron transport chain is linked with oxidative phosphorylation to produce ATP effectively. Some electron transport inhibitors have been obtained from fungi and are being used as anti-infectives in human and animal health and in agriculture. The inhibitors are also very useful tools in helping to elucidate the mechanisms of the electron transport chain. NADH-fumarate reductase is a part of the anaerobic electron transport system found in many helminth parasites. Nafuredin, verticipyrone, and some other new compounds have been isolated from fungal culture broths as NADH-fumarate reductase inhibitors, and some of them and their derivatives show promising anthelmintic activity.

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Authors and Affiliations

  1. The Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

    Mihoko Mori, Kenichi Nonaka, Rokuro Masuma, Satoshi Ōmura & Kazuro Shiomi

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  1. Mihoko Mori
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  2. Kenichi Nonaka
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  4. Satoshi Ōmura
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Correspondence to Satoshi Ōmura or Kazuro Shiomi .

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    Timm Anke

  2. Institut für Biotechnologie und Wirkstoff-Forschung gGmbH (IBWF), Kaiserslautern, Germany

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Mori, M., Nonaka, K., Masuma, R., Ōmura, S., Shiomi, K. (2018). Helminth Electron Transport Inhibitors Produced by Fungi. In: Anke, T., Schüffler, A. (eds) Physiology and Genetics. The Mycota, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-71740-1_10

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