Abstract
Fever is defined as an increase in core body temperature above 38.3 °C (101 °F). It can be considered part of the body’s adaptive and regulated response to infection, trauma, and tissue injury, or it can be considered maladaptive and dysregulated, as when caused by a drug side effect, venous thrombosis, thyroid storm, or a neurological injury. Fever has been shown to enhance the immune response to invading pathogens, while on the other hand, fever increases cardiac output, oxygen consumption, carbon dioxide production, and energy expenditure, which can have untoward effects in those with poor cardiopulmonary reserve, those suffering from neurologic insult, and pregnant patients. Determining the etiology of fever and the appropriate clinical treatment is therefore an important element in improving outcomes for critically ill patients.
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Ross, E., Allison, D., Hobbs, A., Coopwood, B. (2018). New Fever in the Surgical Intensive Care Unit Patient. In: Salim, A., Brown, C., Inaba, K., Martin, M. (eds) Surgical Critical Care Therapy . Springer, Cham. https://doi.org/10.1007/978-3-319-71712-8_43
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