SIRS/Sepsis/Septic Shock/MOSF

  • Thomas J. Herron
  • David J. Ciesla


The systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and multiple organ failure (MOF) refer to a spectrum of physiologic changes resulting from a dysfunctional immune response to infection or tissue injury. Sepsis and septic shock refer to conditions due specifically to the host’s response to infection. In the mildest form, this dysfunctional immune response manifests as SIRS. More severe states progress to end organ dysfunction and failure which have been characterized by a numerous definitions and scoring systems, each with particular advantages and disadvantages.


SIRS MOF Sepsis Septic shock MODS Inflammatory response Immune system 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of South Florida College of MedicineTampaUSA

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