Abstract
In the last decade, the nuclear envelope (NE) has emerged as an important regulator of genome architecture and a central player in gene expression regulation. Nuclear pore complexes (NPCs), the channels that penetrate the NE connecting the nucleus to the cytoplasm, are the largest protein complexes of the NE. Built by multiple copies of roughly 30 different proteins, NPCs were traditionally studied for their role in controlling nucleocytoplasmic transport. But accumulating evidence shows that these massive molecular structures play multiple transport-independent roles that are key for the maintenance of cellular physiology and tissue homeostasis. In this chapter, we will focus on the current knowledge of the role of mammalian NPCs in the regulation of genome organization and gene expression. The recent findings showing that NPCs regulate the activity of specific genes either at the nuclear periphery or inside the nucleus point towards these structures as critical controllers of genome function. Deciphering the molecular mechanism employed by NPCs to modulate specific gene expression programs and to maintain genome integrity are our main challenges for the next decade.
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Raices, M., D’Angelo, M.A. (2018). Nuclear Pore Complexes in the Organization and Regulation of the Mammalian Genome. In: D’Angelo, M. (eds) Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer, Cham. https://doi.org/10.1007/978-3-319-71614-5_7
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