Neurohormonal Procedures in Obesity Treatment

  • Sara A. Morrison
  • Sajani N. Shah


Bariatric surgery is one of the most effective methods for achieving sustainable weight loss, though it can be associated with treatment failures, risks, and potential side effects that are not negligible. Neuromodulation techniques offer a novel approach to the treatment and prevention of obesity and related comorbidities through less invasive means while simultaneously offering a lower side effect profile. Vagal blockade, deep brain stimulation, and bariatric vascular embolization are three of the most promising techniques currently emerging in the field of neuromodulation for the treatment of obesity. Here we review the pathophysiology and rationale behind these approaches, as well as the current evidence in the literature and future applications for their use.


Obesity Vagal nerve blocking Neuromodulation Deep brain stimulation Lateral hypothalamus Nucleus accumbens Reward pathway Binge eating Embolization Ghrelin Left gastric artery Bariatric 



Body mass index


Deep brain stimulation


Diabetes mellitus


Excess weight loss


Hemoglobin A1c


High-density lipoprotein


Low-density lipoprotein


Total weight loss


Vagal nerve blockade


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryTufts Medical CenterBostonUSA

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