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Cardiac Cell Culture Microtechnologies Based on Stem Cells

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Abstract

Stem cells (SCs) are the main source of biological material used in cell therapy and tissue engineering . Additionally, these cells are being investigated as a potential therapy technique for cardiovascular diseases (CVDs) and heart regeneration . To improve the investigation of SC proliferation and maturation, the Lab-on-a-Chip systems are being developed. There are many reports, which have proven that such microsystems have been successfully used for SC differentiation into different cell lineages. In this chapter, we present Heart-on-a-chip systems based on stem cells —the microsystems utilized for SC differentiation into cardiomyocytes (CMs). Various types of SC differentiation performed in Lab-on-a-chip systems are presented at the beginning of this chapter. Next, biochemical, physical and mechanical stimulations are presented as techniques to perform cardiogenesis. Other promising methods, especially the use of graphene and their other forms, which could be used for cardiac differentiation, are presented at the end of this chapter. Finally, we summarize the research focused on heart regeneration using the Lab-on-a-chip systems , and we outline future perspectives for microsystem usage for SC differentiation into CMs.

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Acknowledgements

This work was realized with the frame of project LIDER No. LIDER/026/573/L-4/12/NCBR/2013.

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Authors and Affiliations

  1. The Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

    Anna Kobuszewska, Patrycja Sokolowska & Elzbieta Jastrzebska

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  1. Anna Kobuszewska
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  2. Patrycja Sokolowska
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  3. Elzbieta Jastrzebska
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Correspondence to Elzbieta Jastrzebska .

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Editors and Affiliations

  1. The Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

    Zbigniew Brzozka

  2. The Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

    Elzbieta Jastrzebska

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Kobuszewska, A., Sokolowska, P., Jastrzebska, E. (2018). Cardiac Cell Culture Microtechnologies Based on Stem Cells. In: Brzozka, Z., Jastrzebska, E. (eds) Cardiac Cell Culture Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-70685-6_9

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  • DOI: https://doi.org/10.1007/978-3-319-70685-6_9

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