Tumor Lysis in Neonates and Infants
Tumor lysis syndrome is a massive lysis of malignant cells due to quick proliferation, and it is characterized by hyperuricemia, hyperkalemia, and hyperphosphatemia. Hyperphosphatemia may lead to hypocalcemia. Tumor lysis syndrome usually develops after the start of chemotherapy and may lead to acute renal failure and death, due to renal tubular precipitation of uric acid and other complications. The risk factors for development of tumor lysis syndrome are malignancies with large growth fraction (i.e. B-cell and T-cell lymphomas/leukemias), large tumor bulk, use of cytolytic chemotherapy, pre-existing renal insufficiency, kidney involvement, ureteral or bladder obstruction by the tumor, and metabolic abnormalities .
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